The therapeutic role of Aronia melanocarpa on cyclophosphamide-induced premature ovarian failure

Basit Öğe Kaydı
dc.contributor.authorCelik, Huemeyra
dc.contributor.authorKara, Sinem
dc.contributor.authorBozat, Bihter Gokce
dc.contributor.authorUluc, Firdevs
dc.contributor.authorCetinkaya, Ayhan
dc.contributor.authorFirat, Tulin
dc.date.accessioned2026-01-24T12:26:54Z
dc.date.available2026-01-24T12:26:54Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe purpose of the study was to evaluate the effects of Aronia melanocarpa (A. melanocarpa) extract on ovarian cell apoptosis, vascularization, and follicle reserve in the premature ovarian failure (POF) induced by cyclophosphamide (CYC). After creating a premature ovarian failure model with 100 mg/kg CYC, A. melanocarpa was given to Wistar albino female rats by gavage 15 times every other day (200 mg/kg).Vaginal smears were taken to evaluate the estrus cycles before, during and at the end of the experiment. Histological ovarian follicle count was performed by examining the ovaries with Hematoxylin&Eosin staining. Immunohistochemical evaluation of apoptosis markers of caspase-3 (cas-3), caspase-9 (cas-9) and vascular endothelial growth factor (VEGF) was performed. A. melanocarpa reregulated the estrus cycles in a similar way to the controls by reducing cas-3 and cas-9 in ovarian cells and increasing the number of ovarian cells. While CYC disrupted ovarian vascularization, A. melanocarpa contributed to ovarian reserve by increasing VEGF immunopositivity. In chemotherapy-induced POF, A. melanocarpa extract increases ovarian reserve by providing vascularization, decreasing apoptosis and providing cycle control in female rats.
dc.identifier.endpage2136
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85213019834
dc.identifier.scopusqualityQ3
dc.identifier.startpage2126
dc.identifier.trdizinid1339256
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1339256
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5023
dc.identifier.volume28
dc.identifier.wosWOS:001407427700026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Fac Pharmacy
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAronia melanocarpa
dc.subjectpremature ovarian failure
dc.subjectcyclophosphamide
dc.subjectVEGF
dc.subjectapoptosis.
dc.titleThe therapeutic role of Aronia melanocarpa on cyclophosphamide-induced premature ovarian failure
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu