Analysis of routine blood markers for predicting amputation/re-amputation risk in diabetic foot

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dc.contributor.authorGülcü, Anıl
dc.contributor.authorEtli, Mustafa
dc.contributor.authorKarahan, Oğuz
dc.contributor.authorAslan, Ahmet
dc.date.accessioned2021-02-19T21:16:17Z
dc.date.available2021-02-19T21:16:17Z
dc.date.issued2020
dc.departmentALKÜ
dc.descriptionETLI, MUSTAFA/0000-0001-9320-3971; Aslan, Ahmet/0000-0001-5797-1287; Gulcu, Anil/0000-0002-9012-8053
dc.description.abstractDiabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re-amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee-disarticulation, above-knee amputation) and re-amputations recorded and compared with routine blood parameters. Re-amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (P < 0.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re-amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re-amputation. The statistically optimal HbA1c cutoff point for diabetes was >= 7.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re-amputation possibility.
dc.identifier.doi10.1111/iwj.13491
dc.identifier.endpage2004en_US
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue6en_US
dc.identifier.pmid33021061
dc.identifier.scopusqualityQ1
dc.identifier.startpage1996en_US
dc.identifier.urihttps://doi.org/10.1111/iwj.13491
dc.identifier.urihttps://hdl.handle.net/20.500.12868/357
dc.identifier.volume17en_US
dc.identifier.wosWOS:000575112600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Wound Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamputation levels
dc.subjectblood parameters
dc.subjectdiabetic foot
dc.subjectHbA1c
dc.subjectre-amputation
dc.titleAnalysis of routine blood markers for predicting amputation/re-amputation risk in diabetic foot
dc.typeArticle

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