Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms

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dc.contributor.authorSamur, Dilara Nemutlu
dc.contributor.authorArslan, Rana
dc.contributor.authorAydın, Şule
dc.contributor.authorBektaş, Nurcan
dc.date.accessioned2021-02-19T21:16:08Z
dc.date.available2021-02-19T21:16:08Z
dc.date.issued2018
dc.departmentALKÜ
dc.descriptionSAMUR, DILARA NEMUTLU/0000-0003-2630-6182
dc.description.abstractThe purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model induced by chronic constriction injury in rats, by using dynamic plantar test and plantar test (Hargreaves method), and to evaluate that the possible role of certain serotonin, noradrenergic, opioid and GABAergic receptors by pretreatment with 1 mg/kg (i.p.) ketanserin, yohimbine, naloxone and 0.5 mg/kg (i.p.) bicuculline, respectively. 70 and 100 mg/kg valnoctamide significantly increased the mechanical and thermal thresholds decreasing with the development of neuropathy and demonstrated anti-allodynic and antihyperalgesic activity. Limited contribution of serotonin 5-HT2A/2C receptors and alpha 2-adrenoceptors, and significant contribution of GABA(A) and opioid receptors to the anti-allodynic activity have been identified whereas remarkable contribution of opioid receptors and significant contribution of serotonin 5-HT2A/2C receptors, alpha 2-adrenoceptors, GABA(A) receptors to the antihyperalgesic activity have been identified. Based upon these findings and considering that valnoctamide has safer side-effect profile, it is possible to say that valnoctamide is a potential agent that might be used alone or in combination with the other effective therapies in the alleviating of neuropathic pain.
dc.description.sponsorshipAnadolu University Research Foundation (Eskisehir, Turkey)Anadolu University [AUBAP-1409S395]
dc.description.sponsorshipThis article is based on the M.Sc. degree thesis of Dilara Nemutlu Samur and supported financially the Anadolu University Research Foundation (Eskisehir, Turkey), Project no: AUBAP-1409S395.
dc.identifier.doi10.1016/j.ejphar.2018.03.006
dc.identifier.endpage214en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid29522726
dc.identifier.scopusqualityQ1
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2018.03.006
dc.identifier.urihttps://hdl.handle.net/20.500.12868/266
dc.identifier.volume827en_US
dc.identifier.wosWOS:000428947200023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectValnoctamide
dc.subjectNeuropathic pain
dc.subjectChronic constriction injury
dc.titleValnoctamide: The effect on relieving of neuropathic pain and possible mechanisms
dc.typeArticle

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