Electrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activity

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dc.authorid0000-0002-8212-7149
dc.authorid0000-0001-9865-1685
dc.authorid0000-0002-3394-2438
dc.authorid0000-0001-8791-235X
dc.contributor.authorTurel, Canan Akunal
dc.contributor.authorCelik, Humeyra
dc.contributor.authorCetinkaya, Ayhan
dc.contributor.authorTurel, Idris
dc.date.accessioned2026-01-24T12:29:13Z
dc.date.available2026-01-24T12:29:13Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe aim of our study is to investigate the electrophysiological and anti-inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2-4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125 min, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL-1 beta, IL-6, and TNF-alpha values. It was observed that the co-administration of diclofenac potassium and diazepam at 51-55, 56-60, 61-65, 111-115, and 116-120 min was more effective in reducing spike amplitude than diclofenac potassium alone (p < 0.05). Single-dose diclofenac potassium did not have an anti-inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.
dc.description.sponsorshipAbant Izzet Baysal UEniversitesi [2021.08.32.1488]
dc.description.sponsorshipAbant Izzet Baysal UEniversitesi, Grant/Award Number: 2021.08.32.1488.
dc.identifier.doi10.14814/phy2.15800
dc.identifier.issn2051-817X
dc.identifier.issue17
dc.identifier.pmid37688418
dc.identifier.scopus2-s2.0-85170270127
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.14814/phy2.15800
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5209
dc.identifier.volume11
dc.identifier.wosWOS:001064442500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPhysiological Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectacute seizure
dc.subjectanti-inflammatory
dc.subjectdiclofenac potassium
dc.subjectelectrophysiology
dc.subjectpenicillin-induced
dc.subjectepileptiform activity
dc.titleElectrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activity
dc.typeArticle

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