Green Electrospun Poly(vinyl alcohol)/Gelatin-Based Nanofibrous Membrane by Incorporating 45S5 Bioglass Nanoparticles and Urea for Wound Dressing Applications: Characterization and In Vitro and In Vivo Evaluations

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dc.authorid0000-0002-6288-2091
dc.authorid0009-0006-5374-9316
dc.authorid0000-0002-4805-0993
dc.contributor.authorTemel-Soylu, Tulay Merve
dc.contributor.authorKececiler-Emir, Ceren
dc.contributor.authorRababah, Taha
dc.contributor.authorOzel, Cem
dc.contributor.authorYucel, Sevil
dc.contributor.authorBasaran-Elalmis, Yeliz
dc.contributor.authorAltan, Dilan
dc.date.accessioned2026-01-24T12:31:20Z
dc.date.available2026-01-24T12:31:20Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThis study reports the fabrication and characterization of poly(vinyl alcohol) (PVA) and gelatin (Gel)-based nanofiber membranes cross-linked with citric acid (CA) by a green electrospinning method in which nano 45S5 bioglass (BG) and urea were incorporated. Various combinations of PVA, gelatin, and BG were prepared, and nanofiber membranes with average fiber diameters between 238 and 595 nm were fabricated. Morphological, chemical, and mechanical properties, porosity, swelling, water retention, and water vapor transmission rate of the fabricated membranes were evaluated. PVA:Gel (90:10), 15% CA, and 3% BG were determined as the optimum blend for nanofiber membrane fabrication via electrospinning. The membrane obtained using this blend was further functionalized with 10% w/w polymer urea coating by the electrospray method following the cross-linking. In vitro biocompatibility tests revealed that the fabricated membranes were all biocompatible except for the one that functionalized with urea. In vivo macroscopic and histopathological analysis results of PVA/Gel/BG and PVA/Gel/BG/Urea treated wounds indicated increased collagenization and vascularization and had an anti-inflammatory effect. Furthermore, careful examination of the in vivo macroscopic results of the PVA/Gel/BG/Urea membrane indicated its potential to decrease uneven scar formation. In conclusion, developed PVA/Gel/BG and PVA/Gel/BG/Urea electrospun membranes with multifunctional and biomimetic features may have the potential to be used as beneficial wound dressings.
dc.description.sponsorshipT?rkiye Bilimsel ve Teknolojik Arastirma Kurumu [FBA-2021-4219]; Yildiz Technical University Scientific Research Projects Coordination Unit [YOK, YOK 100/2000]; Council of Higher Education; National PhD Scholarship Program [2250]; TUBITAK
dc.description.sponsorshipThe authors would like to acknowledge that this paper is submitted in partial fulfillment of the requirements for PhD degree at Yildiz Technical University. This work has been supported by Yildiz Technical University Scientific Research Projects Coordination Unit under project number FBA-2021-4219. This study was carried out considering the priority area vision of YOK 100/2000 doctoral project. Tulay Merve TEMEL-SOYLU and Dilan ALTAN would like to thank the financial support by the Council of Higher Education (YOK) under the YOK 100/2000 National PhD Scholarship Program. Cem OZEL also thanks the financial support from the TUBITAK under the BIDEB/2211-A National PhD Scholarship Program and 2250 - Performance-Based Scholarships Programme for PhD.
dc.identifier.doi10.1021/acsomega.4c01102
dc.identifier.endpage21203
dc.identifier.issn2470-1343
dc.identifier.issue19
dc.identifier.pmid38764625
dc.identifier.scopus2-s2.0-85192250873
dc.identifier.scopusqualityQ1
dc.identifier.startpage21187
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c01102
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5821
dc.identifier.volume9
dc.identifier.wosWOS:001228038300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectCross-Linking
dc.subjectPolycarboxylic Acids
dc.subjectPhysical-Properties
dc.subjectSkin Wounds
dc.subjectFabrication
dc.subjectAlcohol)
dc.subjectGelatin
dc.subjectTissue
dc.subjectChallenges
dc.subjectDesign
dc.titleGreen Electrospun Poly(vinyl alcohol)/Gelatin-Based Nanofibrous Membrane by Incorporating 45S5 Bioglass Nanoparticles and Urea for Wound Dressing Applications: Characterization and In Vitro and In Vivo Evaluations
dc.typeArticle

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