Ameliorative effects of agomelatine against doxorubicin-induced hepatotoxicity

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dc.authorid0000-0002-8225-3153
dc.authorid0000-0002-5007-6631
dc.authorid0000-0001-8759-4507
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorSozen, Mehmet Enes
dc.contributor.authorCuce, Gokhan
dc.contributor.authorBatur, Tuba
dc.date.accessioned2026-01-24T12:29:10Z
dc.date.available2026-01-24T12:29:10Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractDrug-induced hepatotoxicity is a significant impediment to the use of doxorubicin, a commonly employed chemotherapeutic agent with established efficacy in cancer treatment. The present study aimed to determine the potential protective effects of agomelatine against doxorubicin hepatotoxicity in rat toxicity models. Thirty-two rats were divided into four groups: control (with saline administration), Doxo (with 40 mg/kg doxorubicin administration), Doxo + Ago20, and Doxo + Ago40 (with 20 and 40 mg/kg agomelatine administration and 40 mg/kg doxorubicin administration). On the day of 14 rats were sacrificed, samples were collected for comparison of immunohistochemical, hematological, and biochemical analysis. There were statistically significant differences between the study groups in terms of immunohistochemical, hematological, and biochemical parameters. Agomelatine administration reduced the TNF-alpha, and caspase-3, which increased by doxorubicin, and reversed levels of oxidative stress markers altered by doxorubicin (p < 0.05). Doxorubicin induces oxidative stress, apoptosis, and hepatotoxicity. Agomelatine may be favored as a primary antidepressant to mitigate hepatic damage induced by doxorubicin.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects Coordination Office
dc.description.sponsorshipThe authors gratefully acknowledge the Alanya Alaaddin Keykubat University Scientific Research Projects Coordination Office for financial support and Halil Asc & imath;, Mehtap Savran, Fatma Nihan Cankara, & Idot;brahim Ayd & imath;n Candan, and Yasemin Sahin for contributions. The preliminary data of this research were presented in summary at the 4th International GAP Mathematics-Engineering-Science and Health Sciences Congress in 2020.
dc.identifier.doi10.1186/s40360-025-00988-y
dc.identifier.issn2050-6511
dc.identifier.issue1
dc.identifier.pmid40781695
dc.identifier.scopus2-s2.0-105012862197
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s40360-025-00988-y
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5178
dc.identifier.volume26
dc.identifier.wosWOS:001549148000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectDoxorubicin
dc.subjectHepatotoxicity
dc.subjectAgomelatine
dc.subjectOxidative stress
dc.subjectCaspase-3
dc.titleAmeliorative effects of agomelatine against doxorubicin-induced hepatotoxicity
dc.typeArticle

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