rTMS reduces delta and increases theta oscillations in Alzheimer's disease: A visual-evoked and event-related potentials study

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dc.authorid0000-0002-6173-9074
dc.authorid0000-0002-2306-5937
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorDudukcu, Esra Zeynep
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorGuntekin, Bahar
dc.contributor.authorAkturk, Tuba
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:01Z
dc.date.available2026-01-24T12:29:01Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for Alzheimer's disease (AD) due to its ability to modulate neural networks and enhance cognitive function. This treatment offers the unique advantage of enabling real-time monitoring of immediate cognitive effects and dynamic brain changes through electroencephalography (EEG).Objective: This study focused on exploring the effects of left parietal rTMS stimulation on visual-evoked potentials (VEP) and visual event-related potentials (VERP) in AD patients.Methods: Sixteen AD patients were recruited for this longitudinal study. EEG data were collected within a Faraday cage both pre- and post-rTMS to evaluate its impact on potentials.Results: Significant alterations were found in both VEP and VERP oscillations. Specifically, delta power in VEP decreased, while theta power in VERP increased post-rTMS, indicating a modulation of brain activities.Discussion: These findings confirm the positive modulatory impact of rTMS on brain activities in AD, evidenced by improved cognitive scores. They align with previous studies highlighting the potential of rTMS in managing hyperexcitability and oscillatory disturbances in the AD cortex.Conclusion: Cognitive improvements post-rTMS endorse its potential as a promising neuromodulatory treatment for cognitive enhancement in AD, thereby providing critical insights into the neurophysiological anomalies in AD and possible therapeutic avenues.
dc.identifier.doi10.1111/cns.14564
dc.identifier.issn1755-5930
dc.identifier.issn1755-5949
dc.identifier.issue1
dc.identifier.pmid38287520
dc.identifier.scopus2-s2.0-85182240626
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/cns.14564
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5082
dc.identifier.volume30
dc.identifier.wosWOS:001142600000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCns Neuroscience & Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAD
dc.subjectrTMS
dc.subjectVEP
dc.subjectVERP
dc.titlerTMS reduces delta and increases theta oscillations in Alzheimer's disease: A visual-evoked and event-related potentials study
dc.typeArticle

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