Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer?s disease: Possible role of BDNF and oxidative stress

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dc.authorid0000-0002-2306-5937
dc.authorid0000-0003-2032-9957
dc.authorid0000-0003-4856-9987
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorBayraktaroglu, Zubeyir
dc.contributor.authorToprak, Guven
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorBektay, Muhammed Yunus
dc.contributor.authorMutlu-Burnaz, Ozlem
dc.date.accessioned2026-01-24T12:31:16Z
dc.date.available2026-01-24T12:31:16Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractRepetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify Brain-Derived Neurotrophic Factor (BDNF) and oxidative stress levels in many neurological and psychiatric diseases, there is still no study evaluating the relationship between memory performance, BDNF, oxidative stress, and resting brain connectivity following rTMS in Alzheimer?s patients. Furthermore, there are increasing clinical data showing that the stimulation of strategic brain regions may lead to more robust improvements in memory functions compared to conventional rTMS. In this study, we aimed to evaluate the possible disease-modifying effects of rTMS on the lateral parietal cortex in AD patients who have the highest connectivity with the hippocampus. To fill the mentioned research gaps, we have evaluated the relationships between resting-state Functional Magnetic Resonance Imaging (fMRI), cognitive scores, blood BDNF levels, and total oxidative/antioxidant status to explain the therapeutic and potential disease-modifying effects of rTMS which has been applied at 20 Hz frequencies for two weeks. Our results showed significantly increased visual recognition memory functions and clock drawing test scores which were associated with elevated peripheral BDNF levels, and decreased oxidant status after two weeks of left lateral parietal TMS stimulation. Clinically our findings suggest that the left parietal region targeted rTMS application leads to significant improvement in familiarity-based cognition associated with the network connections between the left parietal region and the hippocampus.
dc.description.sponsorshipIstanbul Medipol University Research Fund; Research Institute for Health and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN)
dc.description.sponsorshipThis article has been produced from the first author's doctoral dissertation and was supported by Istanbul Medipol University Research Fund. The authors of this work are grateful to Istanbul Medipol University, Research Institute for Health and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN).
dc.identifier.doi10.1016/j.nlm.2021.107410
dc.identifier.issn1074-7427
dc.identifier.issn1095-9564
dc.identifier.pmid33610772
dc.identifier.scopus2-s2.0-85101552098
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.nlm.2021.107410
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5768
dc.identifier.volume180
dc.identifier.wosWOS:000642482000011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofNeurobiology of Learning and Memory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectrTMS
dc.subjectBDNF
dc.subjectImplicit memory
dc.subjectOxidant status
dc.subjectfMRI
dc.titleLeft lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer?s disease: Possible role of BDNF and oxidative stress
dc.typeArticle

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