Pre-earthquake kidney function is a predictor of outcomes in earthquake-related crush syndrome
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background The devastating earthquakes in Kahramanmara & scedil;, T & uuml;rkiye, in February 2024, caused extensive trauma and loss of lives, causing unique challenges in the management of earthquake-related crush syndrome. The current study investigates the prognostic value of pre-earthquake kidney function for mortality prediction in patients diagnosed with crush syndrome. Methods A multi-center retrospective analysis was performed using data from 469 patients treated at 46 nephrology clinics. Pre-earthquake Kidney function, defined by serum creatinine and estimated glomerular filtration rate (eGFR) levels, was obtained from pre-earthquake health records. Clinical findings, laboratory parameters, complications, and survival probabilities were analyzed. Multivariate Cox regression was used to identify independent predictors of in-hospital mortality. Results The mean age of participants was 42.56 +/- 16.92 years (Non-survivors: 50.46 +/- 20.03 years, Survivors: 42.34 +/- 16.80 years (p = 0.172)). The in-hospital mortality rate was 2.8%. Non-survivors exhibited significantly higher pre-earthquake creatinine levels than survivors (1.04 +/- 0.61 mg/dL vs. 0.77 +/- 0.33 mg/dL, p = 0.03), with lower eGFR (85.2 +/- 34.7 mL/min/1.73 m(2 )vs. 115.8 +/- 39.4 mL/min/1.73 m(2 ), p = 0.008). Compared with survivors, non-survivors had higher incidences of AKI (92.3% vs. 61.6%, p = 0.037) and more severe metabolic disturbances, including hyperkalemia (5.41 +/- 1.72 mmol/L vs. 5.13 +/- 0.98 mmol/L, p = 0.008). Regression analysis revealed that pre-earthquake creatinine (HR: 9.121, 95% CI: 2.686-30.970, p < 0.001) and potassium levels at admission (HR: 3.338, 95% CI: 1.540-7.232, p = 0.002) were independent predictors of mortality. Conclusions Pre-earthquake kidney function significantly predicts mortality in crush syndrome patients, highlighting the importance of baseline kidney assessment in disaster preparedness.
Açıklama
Anahtar Kelimeler
Crush syndrome, kidney function, mortality, disaster nephrology, acute kidney injury, hyperkalemia, T & uuml;rkiye
Kaynak
Bmc Nephrology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
26
Sayı
1
