Melatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity via SIRT-1 signaling

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dc.contributor.authorSavran, Mehtap
dc.contributor.authorAşçı, Halil
dc.contributor.authorÖzmen, Özlem
dc.contributor.authorErzurumlu, Yalçın
dc.contributor.authorSavaş, Hasan Basri
dc.contributor.authorSönmez, Yasin
dc.contributor.authorŞahin, Yasemin
dc.date.accessioned2021-02-19T21:16:09Z
dc.date.available2021-02-19T21:16:09Z
dc.date.issued2019
dc.departmentALKÜ
dc.descriptionSahin, Yasemin/0000-0003-4226-674X; asci, halil/0000-0002-1545-035X
dc.description.abstractHigh fructose corn syrup (HFCS) has been shown to cause cardiovascular toxicity via oxidative stress and inflammation. The aim of this study is to demonstrate the protective effects of melatonin (MLT) against HFCS-induced endothelial and cardiac dysfunction via oxidative stress and inflammation. Thirty-two Sprague Dawley male rats were distributed into three groups as control, HFCS, and HFCS + MLT. HFCS form F55 was prepared as 20% fructose syrup solution and given to the rats through drinking water for 10 weeks, and MLT administrated 10 mg/kg/day orally for last 6 weeks in addition to F55. After decapitation, blood and half of the heart samples were collected for biochemical analysis and other half of the tissues for histopathological and immunohistochemical analysis. Aspartate transaminase, creatine kinase MB, lactate dehydrogenase, total oxidant status and oxidative stress index, and caspase-3 levels increased and total antioxidant status levels decreased significantly in HFCS group. MLT treatment reversed all these parameters. Histopathologically, hyperemia, endothelial cell damage and increased levels of angiogenin, C-reactive protein, inducible nitric oxide synthase, myeloperoxidase and decreased sirtuin-1 (SIRT-1) expressions were observed in HFCS group. MLT ameliorated all these changes. MLT has an anti-inflammatory, antioxidant, antiapoptotic effects on HFCS-induced cardiovascular toxicity through enhancing the expression of SIRT-1.
dc.identifier.doi10.1177/0960327119860188
dc.identifier.endpage1223en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue10en_US
dc.identifier.pmid31256681
dc.identifier.scopusqualityQ2
dc.identifier.startpage1212en_US
dc.identifier.urihttps://doi.org/10.1177/0960327119860188
dc.identifier.urihttps://hdl.handle.net/20.500.12868/268
dc.identifier.volume38en_US
dc.identifier.wosWOS:000483554800009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxidative stress
dc.subjectinflammation
dc.subjectapoptosis
dc.subjectcorn syrup
dc.subjectcardiac damage
dc.titleMelatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity via SIRT-1 signaling
dc.typeArticle

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