LoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 signaling

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dc.authorid0000-0003-2134-4067
dc.contributor.authorKar, Fatih
dc.contributor.authorYildiz, Fatma
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Ezgi
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorSenturk, Hakan
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2026-01-24T12:31:19Z
dc.date.available2026-01-24T12:31:19Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIn this study, the effects of the pretreatment of Curcumin and LoxBlock-1 on liver, pancreas, and cardiac dysfunction following Ischemia-Reperfusion-induced (IR) Acute Kidney Injury (AKI) were investigated through the mechanisms of oxidative stress and ferroptosis. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) parameters in the tissue were analyzed to investigate the oxidative stress occurring in the liver, pancreas, and heart, and Acyl-Coa synthetase long-chain family member (ACSL4). Glutathione peroxidase 4 (GPx4) enzyme levels were also analyzed by ELISA to investigate the effect on ferroptosis. In addition, hematoxylin-eosin staining was performed for histopathological examination of the tissues. As a result of biochemical analyzes, it was observed that oxidative stress parameters increased significantly in the IR group. In addition, while the ACSL4 enzyme level increased in the IR group in all tissues, the GPx4 enzyme level decreased. In the histopathological examination, it was observed that IR caused serious damage to the heart, liver, and pancreas tissues. The present study shows that Curcumin and LoxBlock-1 have a protective effect on the liver, pancreas, and cardiac ferroptosis following the effect on AKI. In addition, Curcumin was found to be more effective than LoxBlock-1 in I/R injury with its antioxidant property.
dc.identifier.doi10.1016/j.tice.2023.102114
dc.identifier.issn0040-8166
dc.identifier.pmid37210761
dc.identifier.scopus2-s2.0-85159627498
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.tice.2023.102114
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5801
dc.identifier.volume82
dc.identifier.wosWOS:001012849800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofTissue & Cell
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAKI
dc.subjectRenal IR
dc.subjectCurcumin
dc.subjectLoxBlock-1
dc.subjectFerroptosis
dc.titleLoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 signaling
dc.typeArticle

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