Neutrophil Percentage-to-Albumin Ratio as a Prognostic Marker in Pneumonia Patients Aged 80 and Above in Intensive Care

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dc.authorid0009-0001-5908-4670
dc.authorid0000-0003-4634-205X
dc.authorid0000-0003-2420-7607
dc.authorid0000-0002-5078-3176
dc.authorid0000-0003-3599-2719
dc.contributor.authorAri, Maside
dc.contributor.authorSolay, Asli Haykir
dc.contributor.authorOzdemir, Tarkan
dc.contributor.authorYildiz, Murat
dc.contributor.authorMentes, Oral
dc.contributor.authorTuten, Omer Faruk
dc.contributor.authorManav, Husra Tetik
dc.date.accessioned2026-01-24T12:26:35Z
dc.date.available2026-01-24T12:26:35Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground/Objectives: In recent years, inflammatory markers have been increasingly utilized to predict disease prognosis. The neutrophil percentage-to-albumin ratio (NPAR) has emerged as a novel biomarker reflecting inflammation and systemic response. This study was conducted to evaluate the prognostic value of NPAR in pneumonia patients aged 80 years and older hospitalized in intensive care. Methods: Patients aged 80 years and older who were followed up in the intensive care unit with a diagnosis of pneumonia between 1 October 2022, and 31 May 2024, were retrospectively reviewed. Demographic characteristics, laboratory data, disease severity scores (APACHE II, SOFA), intensive care interventions, and variables associated with mortality were analyzed. NPAR was calculated by dividing the neutrophil percentage by the serum albumin level. The prognostic value of NPAR was assessed using Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curve analysis, and Cox regression analysis. Results: A total of 135 patients were included in the study. Patients with NPAR > 0.286 had significantly higher SOFA (p = 0.002) and APACHE II (p = 0.007) scores. The high NPAR group was at significantly greater risk for requiring invasive mechanical ventilation (p = 0.003), vasopressor support (p = 0.042), and developing sepsis (p = 0.035). Elevated NPAR was strongly associated with mortality (p < 0.001) and was identified as an independent predictor of mortality in the Cox regression analysis (HR = 2.488, 95% CI: 1.167-5.302, p = 0.018). Conclusions: NPAR may serve as an effective biomarker for predicting disease severity and mortality risk in pneumonia patients aged 80 years and older. Due to its simplicity and accessibility, it can be considered a practical parameter for integration into clinical practice. However, large-scale, multicenter, and prospective studies are needed to validate these findings.
dc.identifier.doi10.3390/jcm14093033
dc.identifier.issn2077-0383
dc.identifier.issue9
dc.identifier.pmid40364064
dc.identifier.scopus2-s2.0-105004854033
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14093033
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4768
dc.identifier.volume14
dc.identifier.wosWOS:001486631500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectoldest old
dc.subjectmortality
dc.subjectNPAR
dc.subjectpneumonia
dc.subjectintensive care
dc.titleNeutrophil Percentage-to-Albumin Ratio as a Prognostic Marker in Pneumonia Patients Aged 80 and Above in Intensive Care
dc.typeArticle

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