Morphometric evaluation of cerebral and cerebellar structures in long-term unilateral sensorineural hearing loss

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dc.authorid0009-0006-3409-4561
dc.contributor.authorKubat, Gozde Orhan
dc.contributor.authorOzen, Ozkan
dc.contributor.authorColak, Emre
dc.date.accessioned2026-01-24T12:31:07Z
dc.date.available2026-01-24T12:31:07Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Structural changes in the brain have been identified in patients with hearing loss. However, the effect of long-term Unilateral Sensorineural Hearing Loss (USNHL) on cerebral and cerebellar morphology is not fully understood. Methods: In this study, Magnetic Resonance Imaging (MRI) of 12 long-term USNHL adults was compared with their Normal-Hearing (NH) side using Voxel-Based Morphometry (VBM). The USNHL group was also compared to a control group of 12 hearing-healthy individuals. Volume and cortical thickness changes in cerebral and cerebellar structures, possibly related to hearing loss severity and duration, were assessed using VBM. Results: The study found that, compared to the control group, USNHL patients had significantly higher measurements in the Frontal Operculum (FO) Gray Matter (GM) volume (cm3) (p = 0.024), Superior Temporal Gyrus (STG) thickness (p = 0.041), and cerebellum IX GM volume (cm3) (p = 0.025). No significant differences were observed between the intact and NH sides in the USNHL group (p > 0.05). Conclusion: Cerebral and cerebellar structures, which are essential for perceiving and interpreting sound, integrating information, and coordinating movement, may undergo morphological changes due to neuroadaptive mechanisms in long-term USNHL patients. Larger case series are needed to explore the clinical implications of these changes for diagnosis, treatment, and prognosis. Levels of evidence: Level 3.
dc.identifier.doi10.1016/j.bjorl.2025.101635
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue5
dc.identifier.pmid40344693
dc.identifier.scopus2-s2.0-105004441724
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2025.101635
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5652
dc.identifier.volume91
dc.identifier.wosWOS:001510347500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectHearing loss
dc.subjectUnilateral
dc.subjectGray matter
dc.subjectBrain morphometry
dc.subjectAuditory cortex
dc.titleMorphometric evaluation of cerebral and cerebellar structures in long-term unilateral sensorineural hearing loss
dc.typeArticle

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