Cognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity

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dc.contributor.authorYulug, Burak
dc.contributor.authorYalcinkaya, Ali
dc.contributor.authorSafa, Shair Shah
dc.contributor.authorKarakus, Ayse
dc.contributor.authorSayman, Dila
dc.contributor.authorCankaya, Seyda
dc.contributor.authorSayman, Ceyhun
dc.date.accessioned2026-01-24T12:31:11Z
dc.date.available2026-01-24T12:31:11Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractTension-type headache (TTH) is a widespread primary headache disorder that causes mild to moderate pain, which may be seen together with cognitive deficits. It is unclear if TTH-linked cognitive impairment is associated with functional alterations. Seventy-five participants were enrolled in the study. Mini Mental State Evaluation (MMSE) and Montreal Cognition Assessment (MoCA) tests were applied to evaluate cognitive impairment. A neuroimaging analysis was applied to determine whether the hippocampus responsible for pain and cognition was affected in TTH patients. Our functional data revealed significant alterations in the connectivity of the subiculum, hippocampal fissure, and left whole hippocampus. Among the significant functional brain alterations observed, the right subiculum consistently interacted with MoCA scores and increased pain intensity. Our findings suggest that TTH patients with cognitive impairment may exhibit unique functional alterations in the hippocampus. This suggests a potential negative association between pain modulation and cognitive processes in the hippocampus that may be responsible for the increased risk of dementia in these patients.
dc.identifier.doi10.1016/j.isci.2025.113850
dc.identifier.issn2589-0042
dc.identifier.issue11
dc.identifier.pmid41280692
dc.identifier.scopus2-s2.0-105020811351
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.isci.2025.113850
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5718
dc.identifier.volume28
dc.identifier.wosWOS:001614873200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofIscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectPain
dc.subjectAbnormalities
dc.subjectDepression
dc.subjectExperience
dc.subjectPatterns
dc.subjectState
dc.titleCognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity
dc.typeArticle

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