Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced labor model

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dc.authorid0000-0003-2531-0788
dc.authorid0000-0002-2860-5592
dc.contributor.authorAvci, Sema
dc.contributor.authorGolal, Ezgi
dc.contributor.authorAcar, Nuray
dc.date.accessioned2026-01-24T12:29:12Z
dc.date.available2026-01-24T12:29:12Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAlthough preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabilitation, care, and treatment for postpartum sequelae are high. When evaluated in terms of its causes, infection/inflammation has an important place. Therefore, it is essential to understand the role of pro-and anti-inflammatory proteins in the process. In our study, apelin and apelin receptor (APJ) expression in the cervix-uterus and placental axis were evaluated at tissue and protein levels in pregnant and non-pregnant control, sham, PBS, and LPS groups in the infection model in which LPS induction was performed by midline laparotomy, in CD-1 mice. The evaluation of this axis regarding apelin and apelin receptor in the preterm birth model is new in the literature. Apelin is expressed more intensely in uterine epithelial cells than in the cervix. In the placenta, expression is more intense in the junctional zone compared to other zones. Apelin protein levels decrease significantly in the cervix and placenta whereas it increases in the uterus. While no change was observed in the expres- sion of the apelin receptor at the tissue and protein level in the cervix and uterus, it increased in both aspects in the placenta in the invasive procedure groups. We propose that the decrease in apelin protein due to LPS in the preterm delivery model may be related to the effort to compensate for the balance deteriorated in the pro-inflammatory direction with post-transitional modification at the tissue level. The tendency of apelin to increase with pregnancy has led to the conclusion that it is necessary for a healthy pregnancy. Although the apelin receptor does not change with inflammation, it is necessary to investigate the mechanisms associated with its stress and trauma-induced increase, since it increases in the invasive procedure group.
dc.identifier.doi10.1387/ijdb.230156sa
dc.identifier.endpage100
dc.identifier.issn0214-6282
dc.identifier.issn1696-3547
dc.identifier.issue3
dc.identifier.pmid37937415
dc.identifier.scopus2-s2.0-85176798312
dc.identifier.scopusqualityQ3
dc.identifier.startpage91
dc.identifier.urihttps://doi.org/10.1387/ijdb.230156sa
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5197
dc.identifier.volume67
dc.identifier.wosWOS:001108603500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Basque Country Upv-Ehu Press
dc.relation.ispartofInternational Journal of Developmental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectLPS
dc.subjectinflammation
dc.subjectpreterm birth
dc.subjectapelin
dc.subjectapelin receptor
dc.subjectuterus
dc.subjectcervix
dc.subjectplacenta
dc.titleEvaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced labor model
dc.typeArticle

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