A Retrospective Evaluation of the Cardiometabolic Profile of Patients with COPD-Related Type 2 Respiratory Failure in the Intensive Care Unit

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dc.authorid0000-0003-3599-2719
dc.authorid0000-0002-0968-1549
dc.authorid0000-0003-4634-205X
dc.authorid0000-0002-5397-8841
dc.authorid0000-0002-9449-9302
dc.authorid0000-0001-8127-9995
dc.authorid0000-0001-6467-407X
dc.contributor.authorMentes, Oral
dc.contributor.authorCelik, Deniz
dc.contributor.authorYildiz, Murat
dc.contributor.authorEnsarioglu, Kerem
dc.contributor.authorCirik, Mustafa Ozgur
dc.contributor.authorPeker, Tulay Tuncer
dc.contributor.authorCanbay, Fatma
dc.date.accessioned2026-01-24T12:26:35Z
dc.date.available2026-01-24T12:26:35Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground and Objectives: Chronic obstructive pulmonary disease (COPD) is a notable cause of morbidity and mortality worldwide and can become complicated by Type 2 respiratory failure. This study aimed to analyze the cardiological and metabolic comorbidities of patients admitted to the intensive care unit (ICU) due to COPD-related Type 2 respiratory failure and evaluate their effects on clinical outcomes. Materials and Methods: A retrospective analysis was conducted on 258 patients admitted to the secondary-level pulmonary disease intensive care unit between January 2022 and January 2024. Patients' demographic data, cardiological and metabolic comorbidities, laboratory parameters, and ICU-related variables were evaluated using statistical analysis methods. Results: The most common comorbidities were hypertension (57.0%), congestive heart failure (48.1%), diabetes mellitus (31.4%), and obesity (37.6%). Female patients had significantly higher rates of hypothyroidism, hypertension, obesity, and congestive heart failure compared to males. Patients diagnosed with chronic kidney disease (CKD) had markedly higher cardiothoracic ratios and proBNP levels. ICU length of stay was considerably longer in patients with acute kidney injury (AKI) and coronary artery disease (CAD). Cardiomegaly and obstructive sleep apnea syndrome (OSAS) were more frequently observed in obese patients. Additionally, in COPD patients, a body mass index (BMI) threshold of 25.5 was determined as a cutoff value for radiological cardiomegaly findings with a sensitivity of 69.9% and a specificity of 59.5%. Elevated pCO2 and bicarbonate levels in patients receiving long-term oxygen therapy (LTOT) were associated with advanced-stage COPD. Conclusions: Metabolic and cardiological comorbidities notably impact the clinical prognosis and ICU management of patients diagnosed with COPD and Type 2 respiratory failure. This study, which aims to provide a snapshot of the comorbidities in patients requiring ICU admission due to COPD exacerbation-related Type 2 respiratory failure but without a fatal course, seeks to highlight the key areas where preventive and protective healthcare services should be focused in this patient group. Special attention should be given to monitoring female and obese patients. Future studies should explore how individualized and preventive follow-ups and treatment approaches can improve patient outcomes, with a particular emphasis on these identified areas.
dc.identifier.doi10.3390/medicina61040705
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue4
dc.identifier.pmid40282996
dc.identifier.scopus2-s2.0-105003555556
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina61040705
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4778
dc.identifier.volume61
dc.identifier.wosWOS:001475316700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectCOPD
dc.subjecttype 2 respiratory failure
dc.subjectmetabolic profile
dc.subjectintensive care unit
dc.subjectcomorbidities
dc.subjectobesity
dc.titleA Retrospective Evaluation of the Cardiometabolic Profile of Patients with COPD-Related Type 2 Respiratory Failure in the Intensive Care Unit
dc.typeArticle

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