Effects of propolis coating on antibacterial resistance of intrauterine devices

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dc.authorid0000-0003-1421-9962
dc.authorid0000-0002-3971-7725
dc.authorid0000-0001-5564-5883
dc.contributor.authorDeniz, Alparslan
dc.contributor.authorKarasu, Tunca
dc.contributor.authorIdil, Neslihan
dc.contributor.authorUzun, Lokman
dc.date.accessioned2026-01-24T12:31:26Z
dc.date.available2026-01-24T12:31:26Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntrauterine devices (IUDs) are widely used in preventing fertilization as contracepting devices. In market, they are produced as T-shaped polyethylene (or propylene) and metal (especially copper) composites. Although the metal component is utilized to provide antibacterial efficacy, prolonged implantation and the presence of a wide range of bacteria flora in the intrauterine environment make IUDs susceptible to bacterial contamination, biofilm formation, and unpleasant infection. In the presented study, the propolis, a natural anti-bacterial/-viral product used for different biomedical applications, coating strategy was applied comparatively in three different ways: coating directly on metal components, coating on polymeric material, and using carrying polymer. In addition, antibacterial activity against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli) bacterial strains were investigated by both dynamic bacterial culture (bacterial inhibition activity) and biofilm (biofilm formation resistance) tests. As a result of 48 h of dynamic bacterial culture; it was determined that the antibacterial inhibition efficiency depending on propolis concentration increased up to 99.5% and 98.5% for E. coli and S. aureus, respectively. In addition, the carrying polymer allows IUDs to cover surfaces more homogeneously, as well as improve antibacterial activity. Similarly; it was determined that biofilm formation resistance was improved by 44.33% for E. coli and by 45.99% for S. aureus with both the propolis concentration and the use of carrying polymer. As a result, it has been revealed that propolis will be classified as an alternative, promising, and effective coating agent for improving antibacterial properties and biofilm formation resistance of IUDs.
dc.identifier.doi10.1080/09205063.2023.2285323
dc.identifier.endpage305
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue3
dc.identifier.pmid37982375
dc.identifier.scopus2-s2.0-85177573055
dc.identifier.scopusqualityQ1
dc.identifier.startpage295
dc.identifier.urihttps://doi.org/10.1080/09205063.2023.2285323
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5876
dc.identifier.volume35
dc.identifier.wosWOS:001120765600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Biomaterials Science-Polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectIntrauterine devices
dc.subjectpropolis
dc.subjectantibacterial property
dc.subjectantibiofilm resistance
dc.subjectE. coli
dc.subjectand S. aureus
dc.titleEffects of propolis coating on antibacterial resistance of intrauterine devices
dc.typeArticle

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