Oxidative stress upregulates the transcription of genes involved in thiamine metabolism

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dc.contributor.authorKartal, Burcu
dc.contributor.authorAkçay, Ahmet
dc.contributor.authorPalabıyık, Bedia
dc.date.accessioned2021-02-19T21:16:07Z
dc.date.available2021-02-19T21:16:07Z
dc.date.issued2018
dc.departmentALKÜ
dc.descriptionAkcay, Ahmet/0000-0002-9836-4165; PALABIYIK, Bedia/0000-0002-3395-3081; Kartal, Burcu/0000-0003-2354-7212
dc.description.abstractThiamine is a major vitamin that acts as a cofactor in energy metabolism in all organisms, as well as in lipid and amino acid metabolisms, and is associated with many diseases. It is known that glucose starvation decreases the intracellular thiamine pool while increasing oxidative stress tolerance. Earlier, in whole genome analysis, we detected major differences in the expression of genes related to thiamine pathway against oxidative stress in Schizosaccharomyces pombe. We investigated the effects of oxidative stress and glucose repression to thiamine pathway in S. pombe by comparing some genes encoding key enzymes of each related pathway at the transcription level. In the present study, we found that the expression of genes related to thiamine biosynthesis and transport (thi2, thi3, and pho1) increased in wild type and ird11 cells grown in thiamine-rich media under oxidative stress induced by H2O2. Based on our findings, we suggested that there might be an important effect of oxidative stress on thiamine biosynthesis and transport.
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul UniversityIstanbul University [28781]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1919B011403361]
dc.description.sponsorshipThis research was funded by the Scientific Research Project Coordination Unit of Istanbul University, project ID: 28781, and by The Scientific and Technological Research Council of Turkey, project number: 1919B011403361.
dc.identifier.doi10.3906/biy-1801-51
dc.identifier.endpage452en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue5en_US
dc.identifier.pmid30930628
dc.identifier.scopusqualityQ1
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.3906/biy-1801-51
dc.identifier.urihttps://hdl.handle.net/20.500.12868/253
dc.identifier.volume42en_US
dc.identifier.wosWOS:000448333300008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFission yeast
dc.subjectthiamine
dc.subjectoxidative stress
dc.subjectglucose metabolism
dc.titleOxidative stress upregulates the transcription of genes involved in thiamine metabolism
dc.typeArticle

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