Antipsychotics Induced Reproductive Toxicity by Stimulating Oxidative Stress: A Comparative in Vivo and in Silico Study

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dc.authorid0000-0002-2575-7398
dc.authorid0000-0002-3365-7741
dc.authorid0000-0001-5631-3100
dc.contributor.authorDincer, Busra
dc.contributor.authorBulent Yazici, Ahmet
dc.contributor.authorCinar, Irfan
dc.contributor.authorToktay, Erdem
dc.contributor.authorSelli, Jale
dc.contributor.authorCadirci, Elif
dc.contributor.authorBayraktutan, Zafer
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics-treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics-treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels, Haloperidol and Risperidone are damaging to male reproductivity. This study represents useful starting point for exploring further aspects of the underlying mechanisms reproductive toxicity of antipsychotics.
dc.identifier.doi10.1002/cbdv.202201190
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue5
dc.identifier.pmid37005228
dc.identifier.scopus2-s2.0-85152967795
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/cbdv.202201190
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5446
dc.identifier.volume20
dc.identifier.wosWOS:000973409200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectbiological activity
dc.subjectmedicinal chemistry
dc.subjecttoxicology
dc.titleAntipsychotics Induced Reproductive Toxicity by Stimulating Oxidative Stress: A Comparative in Vivo and in Silico Study
dc.typeArticle

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