Exploring Cognitive Impairment in Patients With Bilateral Capsular Genu Lesions

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dc.authorid0000-0002-0651-7276
dc.contributor.authorKumral, Emre
dc.contributor.authorCetin, Fatma Ece
dc.contributor.authorOzdemir, Huseyin Nezih
dc.contributor.authorCankaya, Seyda
dc.contributor.authorSchabitz, Wolf-Rudiger
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:04Z
dc.date.available2026-01-24T12:29:04Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: The authors investigated for presence of cognitive impairment after occurrence of bilateral lesions of the genu of the internal capsule (GIC). Clinical and neuropsychological features of unilateral GIC lesions have previously been studied, but the cognitive profile of bilateral lesions of the GIC has not been fully explored. Methods: An investigation was conducted of neurocognitive deficits and computerized tomography MRI findings among 4,200 stroke patients with bilateral GIC involvement who were admitted to the hospital between January 2010 and October 2018. Results: Eight patients with bilateral lesions of the capsular genu were identified and their data analyzed. Overall, behavioral and cognitive dysfunction were characterized by impairment of frontal, memory, and executive functions. Attention and abstraction were present among all eight patients (100%); apathy, abulia, and executive dysfunctions, among seven (87.5%); global mental dysfunction and planning deficits, among six (75.0%); short-term verbal memory deficits and language dysfunctions, among five (62.5%); long-term verbal memory deficits, among four (50.0%); and spatial memory deficits, reading, writing, counting dysfunctions, and anarthria, among two (25.0%). Four of the patients (50.0%) without a history of cognitive disorder showed severe mental deterioration compatible with the clinical picture of dementia. A clinical picture of dementia was still present in these patients 6 months after stroke. Conclusions: Bilateral lesions of the capsular genu appearing either simultaneously or at different times were significantly associated with executive dysfunctions.
dc.identifier.doi10.1176/appi.neuropsych.21030086
dc.identifier.endpage267
dc.identifier.issn0895-0172
dc.identifier.issn1545-7222
dc.identifier.issue3
dc.identifier.pmid35040661
dc.identifier.scopus2-s2.0-85135597490
dc.identifier.scopusqualityQ1
dc.identifier.startpage261
dc.identifier.urihttps://doi.org/10.1176/appi.neuropsych.21030086
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5118
dc.identifier.volume34
dc.identifier.wosWOS:000858801700009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Psychiatric Publishing, Inc
dc.relation.ispartofJournal of Neuropsychiatry and Clinical Neurosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectCerebral Hemodynamics
dc.subjectRuptured Aneurysm
dc.subjectInternal Capsule
dc.subjectMemory Loss
dc.subjectInfarction
dc.subjectStroke
dc.subjectAssociation
dc.subjectPerformance
dc.subjectDisorders
dc.subjectCircuits
dc.titleExploring Cognitive Impairment in Patients With Bilateral Capsular Genu Lesions
dc.typeArticle

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