Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial

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dc.authorid0000-0003-0760-0773
dc.contributor.authorArayici, Sema
dc.contributor.authorSimsek, Gulsum Kadioglu
dc.contributor.authorSay, Birgul
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorSari, Fatma Nur
dc.contributor.authorUras, Nurdan
dc.contributor.authorDizdar, Evrim
dc.date.accessioned2026-01-24T12:31:24Z
dc.date.available2026-01-24T12:31:24Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective This study aimed to compare the nasal continuous positive airway pressure (nCPAP) and bi-level positive airway pressure (BiPAP) in preterm infants with respiratory distress syndrome (RDS). Method Preterm infants (<= 32 weeks of gestation) were randomly assigned, at birth, into two study groups: nCPAP or BiPAP. Primary outcomes (surfactant administration and failure of non-invasive respiratory support within the first 72 hours), and secondary outcomes (duration of ventilation support, pneumothorax, bronchopulmonary dysplasia, patent ductus arteriosus, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity, time to total enteral feeding, length of hospital stay, and mortality) were assessed. Results A total of 188 preterm infants with RDS were analysed. Mean gestational age was 28.8 +/- 1.8 weeks (nCPAP) versus 29 +/- 1.9 weeks (BiPAP). There were no statistically significant differences between groups in the failure of non-invasive respiratory support (25% vs. 33%, RR: 0.74, 95% CI: 0.47-1.17) or surfactant administration (35% vs. 38%, RR: 0.92, 95% CI: 0.49-1.71). No significant differences were observed in secondary outcomes between the two groups. Subgroup analysis of infants<30 weeks yielded similar results. Conclusion Although two-level CPAP theoretically offers benefits, BiPAP was not superior to nCPAP as initial support in preterm infants with RDS. This underscores the continued value of the simpler, well-established nCPAP and the need for multicentre trials involving preterm infants of varying gestational ages.
dc.identifier.doi10.1055/a-2546-1381
dc.identifier.issn0300-8630
dc.identifier.issn1439-3824
dc.identifier.pmid40328279
dc.identifier.scopus2-s2.0-105005150826
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1055/a-2546-1381
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5835
dc.identifier.wosWOS:001482077700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofKlinische Padiatrie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectBi-level positive airway pressure
dc.subjectNasal continuous positive airway pressure
dc.subjectNon-invasive respiratory support
dc.subjectRespiratory distress syndrome
dc.subjectSurfactant
dc.titleNasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial
dc.title.alternativeNasales CPAP und BiPAP als initiale Atemunterstützung bei Frühgeborenen: Eine randomisierte kontrollierte Studie
dc.typeArticle

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