Parabiosis Improves Endothelial Dysfunction in Aged Female Mice

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dc.authorid0000-0002-8192-906X
dc.authorid0000-0002-8935-1477
dc.contributor.authorFarisoglu, Ulfet
dc.contributor.authorBalcioglu, Ozlem
dc.contributor.authorOzcem, Barcin
dc.contributor.authorKilic, Ali Onder
dc.contributor.authorSoyler, Gizem
dc.contributor.authorUlker, Seher Nasircilar
dc.contributor.authorKocer, Gunnur
dc.date.accessioned2026-01-24T12:31:16Z
dc.date.available2026-01-24T12:31:16Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntroduction: The study aims to investigate the effect of parabiosis method on endothelial dysfunction in naturally aging mice and determine the time projections for predicted improvement in the mentioned target group. Methods: The balb/c mice were separated into six groups, these being; isochronic old, heterochronic old (HP-O), isochronic young, heterochronic young, young control, and old control. After parabiosis protocol, animals were sacrificed at the third, fifth, seventh, and ninth weeks, and their thoracic aortas were isolated. The vasodilatation and vasoconstriction responses of the vessels were detected using potassium chloride and phenylephrine, acetylcholine (ACh), and sodium nitroprusside. Results: Aging had a significant decreasing effect on maximum ACh relaxation responses (P < 0.01). However, in the HP-O group, the maximum ACh relaxation response in the third week was significantly lower (P < 0.05), but this effect disappeared in the ninth week. Maximum phenylephrine contraction responses were lower in the heterochronic parabiosis group (P < 0.05). Conclusions: ACh responses increased at the end of the ninth week in the HP-O group, therefore, the parabiosis model may have an improving effect on endothelial dysfunction seen in aging. (C) 2022 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2022.04.054
dc.identifier.endpage131
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.pmid35598495
dc.identifier.scopus2-s2.0-85130811449
dc.identifier.scopusqualityQ1
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.1016/j.jss.2022.04.054
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5754
dc.identifier.volume278
dc.identifier.wosWOS:000861737000006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAging
dc.subjectendothelial dysfunction
dc.subjectNO
dc.subjectParabiosis
dc.titleParabiosis Improves Endothelial Dysfunction in Aged Female Mice
dc.typeArticle

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