Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits

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dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorPolat, Derya Çicek
dc.contributor.authorGünal, Mehmet Y.
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorBiçeroğlu, Özge
dc.date.accessioned2021-02-19T21:16:10Z
dc.date.available2021-02-19T21:16:10Z
dc.date.issued2018
dc.departmentALKÜ
dc.descriptionGunal, Mehmet/0000-0001-7702-2441; okur, mehmet evren/0000-0001-7706-6452; Ayla, Sule/0000-0003-2143-5268
dc.description.abstractObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, HPLC, phenolic and flavonoid compounds analyses were performed. MethodsThe wound healing effect was tested by excisional wound model. Wound closure was measured for 14days and at 14th day wound healing was assessed by levels of TGF-, VEGF, COL1A1 and angiogenesis, granulation tissue thickness, epidermal and dermal regeneration. The antioxidant activity was calculated by DPPH and ABTS free radical scavenging assays. Antimicrobial ability was evaluated by minimum inhibitory concentration and agar well diffusion tests. Key findingsThe extract indicated significant antioxidant activity while it also exhibited antimicrobial activity. Rutin was found in the extract according to HPLC study. Moreover, the extract was found to have rich phenolic and flavonoid contents. Histological evaluation showed that extract group induced significant (P<0.001) wound healing activity compared to control group. Furthermore, extract group increased wound healing rates by promoting granulation tissue, epidermal regeneration, angiogenesis, collagen, TGF- and VEGF. ConclusionsThe results clarified that the extract possesses antioxidant, antimicrobial activity and thus could provide a valuable contribution to the wound healing.
dc.identifier.doi10.1111/jphp.12977
dc.identifier.endpage1413en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue10en_US
dc.identifier.pmid29984824
dc.identifier.scopusqualityQ2
dc.identifier.startpage1401en_US
dc.identifier.urihttps://doi.org/10.1111/jphp.12977
dc.identifier.urihttps://hdl.handle.net/20.500.12868/283
dc.identifier.volume70en_US
dc.identifier.wosWOS:000443809400012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Pharmacy And Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantimicrobial
dc.subjectantioxidant
dc.subjectCapparis ovata var
dc.subjectpalaestina
dc.subjectextract
dc.subjectwound healing
dc.titleNovel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
dc.typeArticle

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