The ameliorative effects of hesperidin in rats developed hepatotoxicity with deltamethrin

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dc.authorid0000-0002-8763-0480
dc.contributor.authorKarabekir, Seda Cetinkaya
dc.contributor.authorSozen, Mehmet Enes
dc.contributor.authorAyan, Ilknur Cinar
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorCuce, Gokhan
dc.contributor.authorKalkan, Serpil
dc.date.accessioned2026-01-24T12:29:20Z
dc.date.available2026-01-24T12:29:20Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective(s): Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural antioxidant, against DLM-induced liver toxicity. Materials and Methods: Thirty-two male Wistar Albino rats (250-300 g, 4 months old) were divided into four groups. The control group received 1 ml of corn oil via oral gavage for 30 days. The DLM group received 1.28 mg/kg DLM in corn oil for 30 days. The DLM+HSP 100 mg/kg and DLM+HSP 300 mg/kg groups received 1.28 mg/kg DLM followed by 100 mg/kg or 300 mg/kg HSP in distilled water, respectively, 30 min after DLM administration for 30 days. Liver tissues were examined histopathologically. Masson's trichrome staining and PCR assessed fibrosis. Caspase 3 and 9 expressions in liver tissues were determined by immunohistochemistry and PCR. Biochemical analyses were conducted on serum samples. Results: HSP supplementation led to a dose-dependent decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. DLM exposure decreased antioxidant capacity, while HSP supplementation increased it dose-dependently. Histopathological evaluations showed increased liver damage in the DLM group, while HSP administration reduced liver toxicity. Masson's trichrome staining and analysis of collagen I (COL1A1) and collagen III (COL3A1) gene expression revealed increased fibrosis in the DLM group, which was attenuated with HSP treatment. Conclusion: The potential prevention of DLM-induced liver toxicity and apoptosis by HSP may be an alternative protective strategy.
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Office [KBP.2021.011]
dc.description.sponsorshipFunding This project was supported by the Necmettin Erbakan University Scientific Research Projects Coordination Office (Project No: KBP.2021.011)
dc.identifier.doi10.22038/ijbms.2025.82598.17854
dc.identifier.endpage936
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue7
dc.identifier.pmid40703754
dc.identifier.scopus2-s2.0-105003747065
dc.identifier.scopusqualityQ2
dc.identifier.startpage929
dc.identifier.urihttps://doi.org/10.22038/ijbms.2025.82598.17854
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5296
dc.identifier.volume28
dc.identifier.wosWOS:001477003400013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectClassical Apoptosis
dc.subjectHesperetin-
dc.subject7-Rhamnoglucoside
dc.subjectInsecticides
dc.subjectOxidative Stresses
dc.subjectToxicity
dc.titleThe ameliorative effects of hesperidin in rats developed hepatotoxicity with deltamethrin
dc.typeArticle

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