Morphometric evaluation of cerebellar structures in late monocular blindness

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dc.contributor.authorÖzen, Özkan
dc.contributor.authorAslan, Fatih
dc.date.accessioned2021-02-19T21:16:09Z
dc.date.available2021-02-19T21:16:09Z
dc.date.issued2020
dc.departmentALKÜ
dc.description.abstractBackground Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxel-based volumetric analysis system. Methods The segmental volumetric values, cortical thickness, gray matter volumes and percentage ratios of the cerebellar lobules of individuals with LMB due to trauma and in healthy individuals with bilateral sight as the control group were calculated at the volBrain CERES 1.0 website () by using brain 3D fast spoiled gradient recall acquisition in steady-state (3D T1 FSPGR) MRI sequence images in our prospective study. Results We studied 11 subjects with LMB (8 males/3 females) and 11 healthy control subjects (8 males/3 females). The mean age was 41.45 +/- 14.15 and 40 +/- 11.11 years, respectively (p > 0.05). The mean duration of the LMB status was 20.8 +/- 11.2 years. Cerebellar lobule crus II volume and cerebellar lobule VIIB/VIIIA volume/percentage were higher in the LMB group, and mean cerebellar cortical thickness, cerebellar lobule VI-cerebellar lobule crus I-II cortical thickness, and cerebellar lobule VI gray matter volume values were lower in the LMB group (p < 0.05). Conclusion In this study, cerebellar lobule VIIB/VIIIA volume/total percent ratio, cerebellar cortical thickness and cerebellar gray matter volume in the LMB group were found to be different from the control group. To our knowledge, this is the first study to report cerebellar anatomical changes in patients with LMB.
dc.identifier.doi10.1007/s10792-020-01629-5
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.pmid33180280
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10792-020-01629-5
dc.identifier.urihttps://hdl.handle.net/20.500.12868/270
dc.identifier.wosWOS:000588861900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCerebellum
dc.subjectMagnetic resonance imaging
dc.subjectMonocular blindness
dc.subjectVisuospatial cognition
dc.titleMorphometric evaluation of cerebellar structures in late monocular blindness
dc.typeArticle

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