The role of selenium in bevacizumab induced cardiotoxicity

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dc.contributor.authorÖncel, Can Ramazan
dc.contributor.authorÖvey, İshak Suat
dc.date.accessioned2021-02-19T21:16:30Z
dc.date.available2021-02-19T21:16:30Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractOBJECTIVE: We investigated the role of selenium in bevacizumab induced cardiotoxicity and involvement of transient receptor potential vanilloid 1 (TRPV1) channels in cardiomyocytes. MATERIALS AND METHODS: All cells (Human cardiomyocyte cell line) were cultured at 37 degrees C. We divided the cells into seven groups as control, bevacizumab, bevacizumab + capsazepin, bevacizumab + selenium, bevacizumab + selenium + capsazepin, selenium and selenium + capsazepin groups. Cells in the groups were stimulated with capsaicin and inhibited with capsazepin in related experiments for activation and inactivation of TRPV1 channels, respectively. RESULTS: Cytosolic calcium, apoptosis and intracellular ROS production levels were lower in bevacizumab + selenium group than in the bevacizumab group of cardiomyocytes (p < 0.001). Also, values were markedly lower in the bevacizumab + selenium + capsazepine group when compared to the bevacizumab + selenium group (p < 0.001). CONCLUSION: We found that cytosolic calcium, apoptosis, intracellular ROS production levels were increased in bevacizumab induced cardiotoxicity and selenium treatment could have beneficial effects on these parameters (Fig. 5, Ref. 51). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2019_021
dc.identifier.endpage138en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue2en_US
dc.identifier.pmid30793617
dc.identifier.scopusqualityQ2
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_021
dc.identifier.urihttps://hdl.handle.net/20.500.12868/456
dc.identifier.volume120en_US
dc.identifier.wosWOS:000459055600007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectapoptosis
dc.subjectbevacizumab
dc.subjectcardiomyocyte
dc.subjecttransient receptor potential vanilloid 1
dc.subjectselenium
dc.titleThe role of selenium in bevacizumab induced cardiotoxicity
dc.typeArticle

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