A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients

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dc.authorid0000-0002-9704-6173
dc.authorid0000-0002-2306-5937
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorAyyildiz, Behcet
dc.contributor.authorAyyildiz, Sevilay
dc.contributor.authorSutcubasi, Bernis
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorBayraktaroglu, Zubeyir
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:26:34Z
dc.date.available2026-01-24T12:26:34Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIn Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in the pulvinar's subdivisions and total pulvinar voxel-based morphometry (VBM) changes in individuals with AD and healthy controls. A seed-based functional connectivity analysis was applied to the anterior, inferior, lateral, and medial pulvinar in each hemisphere. Furthermore, VBM analysis was carried out to compare gray matter (GM) volume differences in the pulvinar and thalamus between the two groups. Connectivity analysis revealed that the pulvinar subdivisions had decreased connectivity in individuals with AD. In addition, the pulvinar and thalamus in each hemisphere were significantly smaller in the AD group. The pulvinar may have a role in AD-related cognitive impairments and the intrinsic connectivity network changes and GM loss in pulvinar subdivisions suggest the cognitive deterioration occurring in those with AD. HighlightsThe pulvinar may play a role in pathophysiology of cognitive impairments in those with Alzheimer's disease (AD).Decreased structural volume and functional connectivity were found in patients with AD.The inferior pulvinar is functionally the most affected subdivision by AD compared to the others.
dc.identifier.doi10.1002/alz.12850
dc.identifier.endpage2789
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.issue7
dc.identifier.pmid36576157
dc.identifier.scopus2-s2.0-85145302962
dc.identifier.scopusqualityQ1
dc.identifier.startpage2774
dc.identifier.urihttps://doi.org/10.1002/alz.12850
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4759
dc.identifier.volume19
dc.identifier.wosWOS:000904940000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAlzheimers & Dementia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAlzheimer's disease
dc.subjectcognitive impairment
dc.subjectfunctional magnetic resonance imaging
dc.subjectpulvinar
dc.subjectthalamus
dc.subjectvoxel-based morphometry
dc.titleA structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
dc.typeArticle

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