Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes

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dc.contributor.authorŞeflek, H. N.
dc.contributor.authorKalkan, Sabiha
dc.contributor.authorCüce, Gökhan
dc.contributor.authorKılınç, İbrahim
dc.contributor.authorSözen, Mehmet Emin
dc.date.accessioned2021-02-19T21:16:21Z
dc.date.available2021-02-19T21:16:21Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractWe investigated the effects of Nigella sativa oil on ovary volume, nuclear factor-kappaB (NF-kappa B), X-linked inhibitor of apoptosis protein (XIAP) expression, and serum malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS) levels in diabetic rats. We divided 21 adult female rats into three groups: controls, diabetics and diabetics + N. sativa oil. The diabetics + N. sativa oil group was given 0.2mg/kg/day N. sativa oil 6days/week for 4weeks. NF-kappa B and XIAP expression was assessed in ovarian sections using immunohistochemistry. The right and left ovary volumes were calculated using stereology. We also measured serum MDA, SOD, TAS and TOS levels. We found that N. sativa oil reduced hyperglycemia, but not to control levels. N. sativa oil also exhibited antioxidant properties as demonstrated by reduced serum TOS and MDA levels, and increased SOD and TAS levels compared to controls. We found no significant difference in total ovarian volume, XIAP or NF-kappa B expression among the groups, which may be due to the short study period. Our findings suggest that N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.
dc.description.sponsorshipScientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey [141318002]
dc.description.sponsorshipFunding for this research was provided by Scientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey (project 141318002).
dc.identifier.doi10.1080/10520295.2019.1566571
dc.identifier.endpage333en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid30821520
dc.identifier.scopusqualityQ2
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1566571
dc.identifier.urihttps://hdl.handle.net/20.500.12868/390
dc.identifier.volume94en_US
dc.identifier.wosWOS:000482264200004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidants
dc.subjectapoptosis
dc.subjectdiabetes
dc.subjectNigella sativa oil
dc.subjectovary
dc.subjectoxidant
dc.subjectstereology
dc.titleEffects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes
dc.typeArticle

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