Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats?

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dc.contributor.authorBasak, K.
dc.contributor.authorBasak, P. Y.
dc.contributor.authorDoguc, D. K.
dc.contributor.authorAylak, F.
dc.contributor.authorOguztuzun, S.
dc.contributor.authorBozer, B. M.
dc.contributor.authorGultekin, F.
dc.date.accessioned2021-02-19T21:16:10Z
dc.date.available2021-02-19T21:16:10Z
dc.date.issued2017
dc.departmentALKÜ
dc.descriptionBASAK, KAYHAN/0000-0003-1960-8924; Gultekin, Fatih/0000-0003-2888-3215; Bozer, Busra/0000-0002-7280-4417
dc.description.abstractGlutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression in tissues and gene mutations have been reported in association with many neoplastic skin diseases and dermatoses. Widely used artificial food coloring additives (AFCAs) also reported to effect primarily behavioral and cognitive function and cause neoplastic diseases and several inflammatory skin diseases. We aimed to identify the changes in expression of GSTs, CYP1A1, and vascular endothelial growth factor (VEGF) in rat skin which were maternally exposed AFCAs. A rat model was designed to evaluate the effects of maternal exposure of AFCAs on skin in rats. No observable adverse effect levels of commonly used AFCAs as a mixture were given to female rats before and during gestation. Immunohistochemical expression of GSTs, CYP1A1, and VEGF was evaluated in their offspring. CYP1A1, glutathione S-transferase pi (GSTP), glutathione S-transferase alpha (GSTA), glutathione S-transferase mu (GSTM), glutathione S-transferase theta (GSTT), and VEGF were expressed by epidermal keratinocytes, dermal fibroblasts, sebaceous glands, hair follicle, and subcutaneous striated muscle in the normal skin. CYP1A1, GSTA, and GSTT were expressed at all microanatomical sites of skin in varying degrees. The expressions of CYP1A1, GSTA, GSTT, and VEGF were decreased significantly, while GSTM expression on sebaceous gland and hair follicle was increased. Maternal exposure of AFCAs apparently effects expression of the CYP1A1, GSTs, and VEGF in the skin. This prominent change of expressions might play role in neoplastic and nonneoplastic skin diseases.
dc.identifier.doi10.1177/0960327116678297
dc.identifier.endpage1030en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue10en_US
dc.identifier.pmid27852938
dc.identifier.scopusqualityQ2
dc.identifier.startpage1023en_US
dc.identifier.urihttps://doi.org/10.1177/0960327116678297
dc.identifier.urihttps://hdl.handle.net/20.500.12868/285
dc.identifier.volume36en_US
dc.identifier.wosWOS:000411222500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFood coloring additives
dc.subjectgenotoxicity
dc.subjectglutathione-S-transferase
dc.subjectoxidative stress
dc.subjectskin disease
dc.titleDoes maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats?
dc.typeArticle

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