Evaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells

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dc.contributor.authorErdo?an, Ayşe
dc.contributor.authorHaznedar, Ekin
dc.contributor.authorBaşer, Mehmet
dc.date.accessioned2026-01-24T12:20:42Z
dc.date.available2026-01-24T12:20:42Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe treatment of lung cancer continues to be a significant challenge for many oncologists and their patients. Treatment using epidermal growth factor receptor inhibitors is connected to a positive outcome. Cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor (EGFR), in conjunction with monoterpene phenol thymol, is recommended for the treatment of lung cancer. While a mild acne-like skin rash is quite frequent in patients using cetuximab, a severe rash is rare. The goal of the current study was to assess whether thymol could enhance the anticancer effectiveness of cetuximab in A-549, non-small cell lung cancer (NSCLC) cell line. We found that the combination of cetuximab and thymol synergistically suppressed cell proliferation by inducing membrane damaging, oxidative stress, and apoptosis in A-549 cells. Taken together, our results indicate that the combination of thymol and cetuximab could improve anticancer responses and may notably enhance treatment outcomes in NSCLC. © 2025, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
dc.description.sponsorshipAlanya Alaaddin Keykubat Üniversitesi, ALKU, (2023-02-07-LAP01)
dc.identifier.doi10.31594/commagene.1644311
dc.identifier.endpage48
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105010269808
dc.identifier.scopusqualityQ4
dc.identifier.startpage42
dc.identifier.trdizinid1323744
dc.identifier.urihttps://doi.org/10.31594/commagene.1644311
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1323744
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4511
dc.identifier.volume9
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherABADER (Adıyaman Bilimsel Arastırmalar Dernegi)
dc.relation.ispartofCommagene Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260121
dc.subjectapoptosis
dc.subjectcarvacrol
dc.subjectCetuximab
dc.subjectlung cancer
dc.subjectsynergistic anticancer effect
dc.titleEvaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells
dc.title.alternativeTimol’ün Akciğer Kanseri Hücrelerinde Cetuximab'ın Sitotoksisitesi Üzerindeki Etkisinin Değerlendirilmesi
dc.typeArticle

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