Evaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells
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Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ABADER (Adıyaman Bilimsel Arastırmalar Dernegi)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The treatment of lung cancer continues to be a significant challenge for many oncologists and their patients. Treatment using epidermal growth factor receptor inhibitors is connected to a positive outcome. Cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor (EGFR), in conjunction with monoterpene phenol thymol, is recommended for the treatment of lung cancer. While a mild acne-like skin rash is quite frequent in patients using cetuximab, a severe rash is rare. The goal of the current study was to assess whether thymol could enhance the anticancer effectiveness of cetuximab in A-549, non-small cell lung cancer (NSCLC) cell line. We found that the combination of cetuximab and thymol synergistically suppressed cell proliferation by inducing membrane damaging, oxidative stress, and apoptosis in A-549 cells. Taken together, our results indicate that the combination of thymol and cetuximab could improve anticancer responses and may notably enhance treatment outcomes in NSCLC. © 2025, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
Açıklama
Anahtar Kelimeler
apoptosis, carvacrol, Cetuximab, lung cancer, synergistic anticancer effect
Kaynak
Commagene Journal of Biology
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
9
Sayı
1
