Protective and Therapeutic Role of Ginkgo Biloba Extract Through TRPV1 Channels in an in Vitro Alzheimer's Disease Model

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dc.contributor.authorOzsimsek, Ahmet
dc.contributor.authorOvey, Ishak Suat
dc.contributor.authorKaracay, Ertan
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:26Z
dc.date.available2026-01-24T12:29:26Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntroduction: The effect of Ginkgo biloba (GB) on mitochondria dependent TRPV1 ion channels in neuroblastoma cells was investigated by creating an Alzheimer's disease (AD) model.Methods: Okadaic acid was applied on SH-SY5Y cells to create an AD model. After cellular differentiation, the study was organized with the seven main groups, examining the effect of GB on calcium depended TRPV1 channels in neuroblastoma cells AD, has been established in vitro.Results: The higher Ca2+ concentration was detected in the GB+AD, AD and AD+GB groups when compared with the control (p<0.001). The Ca2+ level was lower in GB+AD and AD+GB groups than in the AD group (p<0.001). Also, cytosolic Ca2+ concentration was lower in the GB+AD than in the AD+GB group (p<0.05), the apoptosis and intracellular reactive oxygen species (ROS) values were higher in the GB+AD, AD and AD+GB groups than in the control (p<0.001). The apoptosis and intracellular ROS values were higher in AD group than in the GB+AD and AD+GB group (p<0.001) and the apoptosis level was higher in AD+GB group than GB+AD group (p<0.001) and the mitochondrial depolarization, caspase 3 and caspase 9 levels were higher in the GB+AD, AD and AD+GB groups when compared to the control group (p<0.001). Also, the values were lower in the GB+AD group, AD group and AD+GB groups when compared with the GB+AD+capsazepine group, AD+capsazepine group and AD+GB+capsazepine respectively (p<0.001).Conclusion: These results show us that GB has a protective effect besides its therapeutic effect in Alzheimer's disease via TRPV1 channel.
dc.identifier.doi10.29399/npa.28166
dc.identifier.endpage213
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue3
dc.identifier.pmid37645077
dc.identifier.scopus2-s2.0-85168625732
dc.identifier.scopusqualityQ3
dc.identifier.startpage207
dc.identifier.urihttps://doi.org/10.29399/npa.28166
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5335
dc.identifier.volume60
dc.identifier.wosWOS:001055620100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAlzheimer disease
dc.subjectGinkgo biloba
dc.subjectneuroblastoma cells
dc.subjectROS (reactive oxygen species)
dc.subjectTRPV1
dc.titleProtective and Therapeutic Role of Ginkgo Biloba Extract Through TRPV1 Channels in an in Vitro Alzheimer's Disease Model
dc.typeArticle

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