Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD)

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dc.contributor.authorEtli, Mustafa
dc.contributor.authorCanbolat, Gökhan
dc.contributor.authorKarahan, Oğuz
dc.contributor.authorKoru, Murat
dc.date.accessioned2021-02-19T21:16:12Z
dc.date.available2021-02-19T21:16:12Z
dc.date.issued2021
dc.departmentALKÜ
dc.descriptioncanbolat, gokhan/0000-0001-6491-095X; ETLI, MUSTAFA/0000-0001-9320-3971
dc.description.abstractVascular hemodynamics play an important role in cardiovascular diseases. This work aimed to investigate the effects of an increase in ascending aortic diameter (AAD) on hemodynamics throughout a cardiac cycle for real patients. In this study, two scans of thoracic aortic aneurysm (TAA) subject with different AADs (42.94 mm and 48.01 mm) and a scan of a normal subject (19.81 mm) were analyzed to assess the effects of hemodynamics on the progression of TAA with the same flow rate. Real-patient aortic geometries were scanned by computed tomography angiography (CTA), and steady and pulsatile flow conditions were used to simulate real patient aortic geometries. Aortic arches were obtained from routine clinical scans. Computational fluid dynamics (CFD) simulations were performed with in vivo boundary conditions, and 3D Navier-Stokes equations were solved by a UDF (user-defined function) code defining a real cardiac cycle of one patient using Fourier series (FS). Wall shear stress (WSS) and pressure distributions were presented from normal subject to TAA cases. The results show that during the peak systolic phase pressure load increased by 18.56% from normal subject to TAA case 1 and by 23.8% from normal subject to TAA case 2 in the aneurysm region. It is concluded that although overall WSS increased in aneurysm cases but was low in dilatation areas. As a result, abnormal changes in WSS and higher pressure load may lead to rupture and risk of further dilatation. CFD simulations were highly effective to guide clinical predictions and assess the progress of aneurysm regions in case of early surgical intervention.
dc.identifier.doi10.1007/s11517-020-02287-6
dc.identifier.endpage84en_US
dc.identifier.issn0140-0118
dc.identifier.issn1741-0444
dc.identifier.issue1en_US
dc.identifier.pmid33225424
dc.identifier.scopusqualityQ2
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.1007/s11517-020-02287-6
dc.identifier.urihttps://hdl.handle.net/20.500.12868/310
dc.identifier.volume59en_US
dc.identifier.wosWOS:000591541700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofMedical & Biological Engineering & Computing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectComputational fluid dynamics (CFD)
dc.subjectThoracic aortic aneurysm
dc.subjectCardiovascular flow
dc.subjectComputed tomography angiography
dc.subjectPatient-specific simulation
dc.titleNumerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD)
dc.typeArticle

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