Can we predict preoperative tumor aggressivity with hemogram parameters in renal cell carcinoma? a novel calculation method

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dc.contributor.authorUçar, Murat
dc.contributor.authorSoyupek, Sedat
dc.contributor.authorOksay, Taylan
dc.contributor.authorÖzorak, Alper
dc.contributor.authorAkkoç, Ali
dc.contributor.authorTopçuoğlu, Murat
dc.contributor.authorKoşar, Alim
dc.date.accessioned2021-02-19T21:16:40Z
dc.date.available2021-02-19T21:16:40Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractWe aim to investigate the prognostic significance of the hemoglobin X lymphocyte / neutrophil ratio (HLNR) and hemoglobin x lymphocyte / platelet ratio (HLPR) with tumor aggressivity in patients with renal cell carcinoma. We retrospectively analyzed 127 patients' data who had diagnosed as renal cell carcinoma between 2008 and 2019 in Suleyman Demirel University Hospital. Tumor and patient characteristics, hemoglobin, neutrophil, lymphocyte, platelet values HLNR and HLPR were calculated in preoperative hemogram parameters. The relationship between tumor pathological stage, Fuhrman nuclear grade and tumor necrosis with HLPR and HLNR analyzed with statistically. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLNR. P values are 0.003, 0.012 and 0.015 respectively. HLNR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLPR. P values are 0.001, 0.014 and 0.047 respectively. HLPR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. High pathological stage, high Fuhrman nuclear grade and existence of tumor necrosis are associates with preoperative low HLNR and low HLPR in renal cell carcinoma patients. They can be used as prognostic markers in patients with renal mass preoperatively.
dc.identifier.doi10.1007/s10916-019-1491-2
dc.identifier.issn0148-5598
dc.identifier.issn1573-689X
dc.identifier.issue1en_US
dc.identifier.pmid31823081
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10916-019-1491-2
dc.identifier.urihttps://hdl.handle.net/20.500.12868/515
dc.identifier.volume44en_US
dc.identifier.wosWOS:000513496500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Medical Systems
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKidney
dc.subjectCarcinoma renal cell
dc.subjectHematologic tests
dc.subjectPrognosis
dc.titleCan we predict preoperative tumor aggressivity with hemogram parameters in renal cell carcinoma? a novel calculation method
dc.typeArticle

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