Choroidal thickness and choroidal vascular index in childhood malnutrition

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dc.authorid0000-0003-3320-3739
dc.authorid0000-0002-0708-5508
dc.contributor.authorSukun, Elmas Yuksel
dc.contributor.authorYavrum, Fuat
dc.contributor.authorYavrum, Begum
dc.date.accessioned2026-01-24T12:31:16Z
dc.date.available2026-01-24T12:31:16Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectives: Malnutrition is a global health issue affecting growth and systemic health in children, yet its impact on the choroid-a vascular layer essential for retinal nourishment-remains underexplored. This study evaluates the choroidal vascular index (CVI) and choroidal thickness in malnourished children compared to healthy controls using optical coherence tomography (OCT). It also examines the relationship between these parameters and nutritional markers, including serum ferritin, vitamin B12, vitamin D, and hemoglobin levels. Methods: This cross-sectional study involved 52 malnourished and 40 healthy children aged 6-16 years. Malnutrition severity was categorized as mild, moderate, or severe based on WHO BMI criteria. Choroidal parameters were measured using spectral-domain optical coherence tomography (SD-OCT). Statistical analysis compared CVI and thickness between groups and assessed correlations with malnutrition severity and nutritional markers. Results: CVI was significantly lower in malnourished children compared to controls (P < 0.05), while choroidal thickness showed no significant difference (P > 0.05). CVI negatively correlated with malnutrition severity (r = -0.45, P < 0.01). Ferritin and vitamin D levels were positively associated with CVI (P < 0.001), whereas vitamin B12 showed no significant relationship. Lower hemoglobin levels were linked to vascular compromise. Conclusions: Malnutrition adversely affects CVI, even in early stages, suggesting it as a marker of choroidal vascular compromise. Micronutrients, particularly ferritin and vitamin D, appear protective. Monitoring choroidal parameters and addressing nutritional deficiencies may help prevent ocular complications in malnourished children. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
dc.identifier.doi10.1016/j.nut.2025.112838
dc.identifier.issn0899-9007
dc.identifier.issn1873-1244
dc.identifier.pmid40543247
dc.identifier.scopus2-s2.0-105008579819
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.nut.2025.112838
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5769
dc.identifier.volume138
dc.identifier.wosWOS:001518630900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofNutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMalnutrition
dc.subjectChoroidal thickness
dc.subjectChoroidal vascular index
dc.subjectPediatric population
dc.subjectMicrocirculation
dc.titleChoroidal thickness and choroidal vascular index in childhood malnutrition
dc.typeArticle

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