Investigation of the Antiangiogenic Properties of Zoledronic Acid by Using Chorioallantoic Membrane Model

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dc.contributor.authorGülcü, Anıl
dc.contributor.authorAkkaya, Özgür
dc.date.accessioned2023-10-02T06:34:24Z
dc.date.available2023-10-02T06:34:24Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjective: Zoledronic acid (ZA) is a bisphosphonate-derived agent used in osteoporotic clinical pathologies to prevent the development of complications such as fractures and hypercalcemia by regulating bone metabolism. Studies have been conducted on the antiangiogenic efficacy of this agent, which also has other systemic side effects. In this study, the dose-dependent antiangiogenic activity of ZA was investigated on the chorioallantoic membrane model (CAM). Methods: Three doses (10?4, 10?5, and 10?6 M concentrations) of drug pellets were prepared with ZA and another pellet was prepared as the positive control group with vascular endothelial growth factor (VEGF) inhibitor agent bevacizumab (10?6 M concentration). Thereafter all pellets were placed on chorioallantoic membranes on the fourth day of egg incubation. All eggs were evaluated for capillary development four days after the drug application. Results: The highest antiangiogenic effect was detected in the positive control group. Moreover, incremental antiangiogenic effects were detected with average scores of.9, 1.1, 1.2 in 10?6, 10?5, and 10?4 M concentrations of ZA groups respectively. Conclusion: Our findings supported that ZA has dose-dependent antiangiogenic effects. This result suggests that different dosing may be required in cases where angiogenesis is therapeutic.
dc.identifier.doi10.1177/15593258221093410
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85129217501&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=58&citeCnt=1&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2366
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/15593258221093410
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofDose-Response
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectZoledronic Acid
dc.subjectDose-dependent effects
dc.subjectAntiangiogenesis
dc.titleInvestigation of the Antiangiogenic Properties of Zoledronic Acid by Using Chorioallantoic Membrane Model
dc.typeArticle

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