Nesfatin-1 as a Potential Biomarker for Ischemic Stroke: A Case-Controlled Study of a Comparative Analysis of Patients with and Without Internal Carotid Artery Stenosis

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dc.authorid0000-0002-4619-693X
dc.authorid0000-0002-1611-0875
dc.authorid0000-0002-1413-4523
dc.authorid0000-0002-2227-4104
dc.contributor.authorKati, Sennur Delibas
dc.contributor.authorOzben, Serkan
dc.contributor.authorKucuksayan, Ertan
dc.contributor.authorVan, Mert
dc.contributor.authorCilli, Esra Yegin
dc.contributor.authorYaman, Aylin
dc.contributor.authorOzben, Tomris
dc.date.accessioned2026-01-24T12:29:30Z
dc.date.available2026-01-24T12:29:30Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectives: Recently, the need for early diagnosis of modifiable risk factors involved in the etiology of stroke has been highlighted in the literature. Nesfatin-1 is a peptide expressed in the central nervous system and peripheral tissues and has been used as a biomarker in recent years. This study aimed to determine the association of ischemic stroke with internal carotid artery stenosis according to nesfatin-1 level and whether it could be used as a biomarker. Methods: A total of 118 patients were included in the study. Three groups were defined: acute stroke patients with symptomatic internal carotid artery stenosis, acute stroke patients without internal carotid artery stenosis, and a control group. Nesfatin-1 levels were measured and compared. Results: The median value was 22 pg/mL in acute stroke patients with internal carotid artery stenosis, 24.3 pg/mL in acute stroke patients without internal carotid artery stenosis, and 46.4 pg/mL in the control group. There is a difference between the median values of nesfatin-1 according to the stroke groups with the control group (p < 0.001). When a cut-off value of <= 30.62 was taken for nesfatin-1, an AUC value of 0.773 indicated statistical significance (p < 0.001). Sensitivity was 77.03%, specificity 83.33%, PPV 90.48%, and NPV 63.83%. The main limitations of our study are the small sample size and the fact that the function of nesfatin-1 is not completely known. Conclusions: Although we found that nesfatin-1 levels were lower in ischemic stroke patients compared to controls, its diagnostic potential indicates a moderate discriminatory ability with an AUC value of 0.773. Therefore, whether it is suitable for clinical use will be demonstrated by studies in larger and multicenter cohorts.
dc.identifier.doi10.3390/diagnostics15060664
dc.identifier.issn2075-4418
dc.identifier.issue6
dc.identifier.pmid40150007
dc.identifier.scopus2-s2.0-105001308633
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/diagnostics15060664
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5410
dc.identifier.volume15
dc.identifier.wosWOS:001452806000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectstroke
dc.subjectbiomarker
dc.subjectinternal carotid artery
dc.subjectstenosis
dc.subjectnesfatin-1
dc.titleNesfatin-1 as a Potential Biomarker for Ischemic Stroke: A Case-Controlled Study of a Comparative Analysis of Patients with and Without Internal Carotid Artery Stenosis
dc.typeArticle

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