Chemogenetic inhibition of MCH neurons does not alter memory performance in mice

Basit Öğe Kaydı
dc.authorid0000-0002-7679-3479
dc.authorid0000-0002-3247-613X
dc.authorid0000-0002-2306-5937
dc.contributor.authorMutlu-Burnaz, Ozlem
dc.contributor.authorYulug, Burak
dc.contributor.authorOncul, Merve
dc.contributor.authorCelik, Esref
dc.contributor.authorAtasoy, Nilufer Sayar
dc.contributor.authorCankaya, Seyda
dc.contributor.authorHanoglu, Lutfu
dc.date.accessioned2026-01-24T12:31:07Z
dc.date.available2026-01-24T12:31:07Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractMemory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consoli-dation is one of the most important parts of the memory process, and one that can be affected by numerous neurodegenerative diseases. Hypothalamic melanin-concentrating hormone (MCH) neuronal activity has been of particular interest to researchers in terms of the association between sleep, neurodegenerative diseases, and memory consolidation. We used Pmch-Cre animals to investigate the role of MCH neuronal activity in memory consolidation. In order to observe the differences in memory consolidation, we chemogenetically inhibited MCH neurons using the DREADD method and measured hippocampus-dependent memory performance with a novel object recognition test applicable to early memory impairment in Alzheimer's disease. Our results revealed no significant improvement or worsening with MCH inhibition, suggesting that the role of MCH should now be evaluated in a wider setting.
dc.identifier.doi10.1016/j.biopha.2022.113771
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid36271553
dc.identifier.scopus2-s2.0-85139045097
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2022.113771
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5649
dc.identifier.volume155
dc.identifier.wosWOS:000874520300002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectMemory
dc.subjectMCH
dc.subjectBrain circuits
dc.subjectNovel object recognition test
dc.titleChemogenetic inhibition of MCH neurons does not alter memory performance in mice
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu