Beyond the therapeutic effect of rTMS in alzheimer's disease: A possible neuroprotective role of hippocampal BDNF?: A minireview

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dc.contributor.authorYuluğ, Burak
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKhanmammadov, Elmir
dc.contributor.authorDüz, Özge Ariel
dc.contributor.authorPolat, Burcu
dc.contributor.authorHanoğlu, Taha
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2021-02-19T21:16:20Z
dc.date.available2021-02-19T21:16:20Z
dc.date.issued2018
dc.departmentALKÜ
dc.descriptionGunal, Mehmet/0000-0001-7702-2441; Kilic, Ertugrul/0000-0001-6494-8923
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant neuroprotective and pro-cognitive effects in AD. However, it is nearly impossible directly to evaluate the BDNF expression in humans after rTMS application. Here we summarized the underlying mechanisms of the neuroprotective and procognitive effect of BDNF that can be induced through a region-specific rTMS approach. Additionally, we have also evaluated the role of Magnetic Resonance Spectroscopy in monitoring the BDNF response after rTMS application in Alzheimer's Disease. We have provided strong evidence that rTMS exerts significant neuroprotective and pro-cognitive effects through the expression of hippocampal BDNF. Furthermore, Magnetic Resonance Spectroscopy might play a critical role in monitoring the BDNF response after rTMS application in AD patients. Such a sophisticated approach might be able to enlighten us on the time-dependent cognitive and neuroprotective correlates of the rtMS application in AD patients.
dc.identifier.doi10.2174/1389557517666170927162537
dc.identifier.endpage1485en_US
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.issue17en_US
dc.identifier.pmid28971775
dc.identifier.scopusqualityQ1
dc.identifier.startpage1479en_US
dc.identifier.urihttps://doi.org/10.2174/1389557517666170927162537
dc.identifier.urihttps://hdl.handle.net/20.500.12868/382
dc.identifier.volume18en_US
dc.identifier.wosWOS:000444438600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofMini-Reviews In Medicinal Chemistry
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrTMS
dc.subjectBDNF
dc.subjectMRS
dc.subjecthippocampus
dc.subjectneuroprotective
dc.subjectAD patients
dc.titleBeyond the therapeutic effect of rTMS in alzheimer's disease: A possible neuroprotective role of hippocampal BDNF?: A minireview
dc.typeReview Article

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