Clonal outbreak of Myroides odoratimimus in ICU patients: A descriptive analysis of pan-drug resistance and associated mortality

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dc.contributor.authorKarvar, Sinasi
dc.contributor.authorOkumus, Elif
dc.contributor.authorTutan, Kubra Nur
dc.contributor.authorYesilyurt, Aysun Ozel
dc.date.accessioned2026-01-24T12:31:08Z
dc.date.available2026-01-24T12:31:08Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractMyroides odoratimimus, a non-fermentative Gram-negative bacillus, has increasingly been recognized as a cause of opportunistic healthcare-associated infections, particularly in intensive care units (ICUs). Its intrinsic resistance to multiple antibiotic classes, including carbapenems, aminoglycosides, and polymyxins, presents serious therapeutic challenges. Here, we report a clonal outbreak of urinary M. odoratimimus involving 27 patients over a 7-month period in a tertiary care hospital in Turkey. All patients were hospitalized in ICUs and had indwelling urinary catheters. The isolates were identified using automated systems and confirmed through 16S rRNA gene sequencing. Clonal relatedness was determined by (GTG)5-PCR, demonstrating genetic identity among all isolates despite their detection in different ICU wards. All strains exhibited a pan-drug-resistant phenotype, showing resistance to every tested antimicrobial, including colistin. The mean duration of hospital stay was 61 days, and the mortality rate was 70.3 %, notably exceeding predicted mortality based on APACHE II scores and the background ICU mortality rate. Environmental cultures were all negative, possibly due to delayed sampling or limitations of conventional detection techniques. This study highlights the ability of M. odoratimimus to cause persistent clonal outbreaks in critical care settings, underscores its clinical significance as a multidrug-resistant pathogen, and emphasizes the need for early microbiological identification, molecular surveillance, and robust infection control strategies.
dc.identifier.doi10.1016/j.diagmicrobio.2025.117066
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue4
dc.identifier.pmid40834837
dc.identifier.scopus2-s2.0-105013634578
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2025.117066
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5669
dc.identifier.volume113
dc.identifier.wosWOS:001559507300003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMyroides odoratimimus
dc.subjectNosocomial outbreak
dc.subjectUrinary isolates
dc.subjectPan-drug resistance
dc.subjectClonal dissemination
dc.subjectIntensive care unit
dc.titleClonal outbreak of Myroides odoratimimus in ICU patients: A descriptive analysis of pan-drug resistance and associated mortality
dc.typeArticle

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