Regulation of signaling pathways by Ampelopsin (Dihydromyricetin) in different cancers: Exploring the highways and byways less travelled
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
C M B Assoc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ampelopsin or Dihydromyricetin is gradually emerging as a high-quality natural product because of its ability to modulate wide-ranging signaling pathways. Ampelopsin (Dihydromyricetin) has been reported to effectively modulate growth factor receptor (VEGFR2 and PDGFR beta) mediated signaling, TRAIL/TRAIL-R pathway, JAK/STAT and mTOR-driven signaling in different cancers. Ampelopsin (Dihydromyricetin) has also been shown to exert inhibitory effects on the versatile regulators which trigger EMT (Epithelial-to-Mesenchymal Transition). Findings obtained from in-vitro studies are encouraging and there is a need to comprehensively analyze how Ampelopsin (Dihydromyricetin) inhibits tumor growth in different cancer models. Better knowledge of efficacy of Ampelopsin (Dihydromyricetin) in tumor bearing mice will be helpful in maximizing its translational potential.
Açıklama
Attar, Rukset/0000-0001-8770-9562; Pawlak, Edyta/0000-0002-0386-7940; Buha, Aleksandra/0000-0002-6942-7040; Adylova, Aima/0000-0002-8129-3209
Anahtar Kelimeler
Ampelopsin, Dihydromyricetin, Cancer, Apoptosis, Therapy, Signaling
Kaynak
Cellular And Molecular Biology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
65
Sayı
7
