The Role of WNT3A Protein and Gene Variants in Allergic Rhinitis: A Case-Control Study

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dc.contributor.authorEksi, Durkadin Demir
dc.contributor.authorGunizi, Huseyin
dc.date.accessioned2026-01-24T12:29:29Z
dc.date.available2026-01-24T12:29:29Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAllergic rhinitis (AR) is a prevalent inflammatory disorder of the upper respiratory tract, driven by allergen exposure. Understanding mechanisms and identifying biomarkers for AR could significantly impact diagnosis and treatment. This study aimed to investigate the association between serum Wingless-Type MMTV Integration Site Family, Member 3A (WNT3A) protein levels, WNT3A polymorphisms, and AR. A cohort of 92 AR patients and 86 healthy controls was recruited. Serum WNT3A levels were measured by enzyme-linked immunosorbent assay (ELISA). WNT3A gene polymorphisms (rs752107 and rs3121310) were analyzed using Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) method. The study revealed significantly higher serum WNT3A levels in AR patients compared to controls (p < 0.0001). The impact of WNT3A in the differential diagnosis of AR was determined to be moderate, with an area under the curve (AUC) value of 0.67 (95% Confidence Interval: 0.59-0.75) based on the receiver operating characteristic (ROC) curve analysis. The rs3121310 polymorphism showed a significant association with the GA genotype more prevalent in controls (p < 0.05). However, no significant relationship was observed between rs3121310 genotypes and clinical parameters of the patients. These findings suggest a role for WNT3A in AR pathogenesis, given the elevated serum levels in patients. Larger cohort studies are needed to validate these findings and explore serum WNT3A levels as a biomarker for AR diagnosis and treatment monitoring.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects Unit; [2021-04-01-MAP04]
dc.description.sponsorshipThis research was funded by Alanya Alaaddin Keykubat University Scientific Research Projects Unit, grant number 2021-04-01-MAP04.
dc.identifier.doi10.3390/cimb46090565
dc.identifier.endpage9533
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue9
dc.identifier.pmid39329917
dc.identifier.scopus2-s2.0-85205125425
dc.identifier.scopusqualityQ3
dc.identifier.startpage9523
dc.identifier.urihttps://doi.org/10.3390/cimb46090565
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5408
dc.identifier.volume46
dc.identifier.wosWOS:001326519500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectallergic rhinitis
dc.subjectWNT3A
dc.subjectpolymorphisms
dc.subjectbiomarkers
dc.subjectgenetics
dc.subjectrespiratory allergies
dc.titleThe Role of WNT3A Protein and Gene Variants in Allergic Rhinitis: A Case-Control Study
dc.typeArticle

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