The Contribution of the Renin-Angiotensin System to Alzheimer’s Disease

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dc.contributor.authorGüzel, Özge
dc.contributor.authorKehoe, Patrick G.
dc.date.accessioned2026-01-24T12:20:49Z
dc.date.available2026-01-24T12:20:49Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe renin-angiotensin system (RAS) is becoming increasingly recognised as a biochemical pathway relevant to the development and progression of Alzheimer’s disease (AD). RAS involvement in AD was initially linked to AD via numerous genetic association studies and more recent Genome-Wide Association Studies (GWAS), and in some cases in relation to classical hallmarks of AD pathology. Since these initial findings, which will be summarised here, several complementary areas of research are converging in support of what has been proposed as the Angiotensin Hypothesis for Alzheimer’s disease. This hypothesis proposes how the RAS and disease-associated changes to the normal balance between opposing regulatory pathways within RAS warrant careful consideration in the pathogenesis of AD and its pathology. We discuss some of these in relation to RAS-targeting therapeutics, originally developed for the treatment of cardiovascular conditions, and how they might be repurposed as interventions for AD. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
dc.identifier.doi10.1007/7854_2024_525
dc.identifier.endpage127
dc.identifier.isbn9783642137167
dc.identifier.isbn9783642200052
dc.identifier.isbn9783642197024
dc.identifier.isbn9783642151309
dc.identifier.isbn9783642030000
dc.identifier.isbn9783642354243
dc.identifier.isbn9783540889540
dc.identifier.isbn9783642157561
dc.identifier.isbn9783642029110
dc.identifier.issn1866-3370
dc.identifier.pmid39543022
dc.identifier.scopus2-s2.0-105003243609
dc.identifier.scopusqualityQ2
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.1007/7854_2024_525
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4608
dc.identifier.volume69
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofCurrent Topics in Behavioral Neurosciences
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260121
dc.subjectAlzheimer’s disease
dc.subjectAngiotensin-converting enzyme-1
dc.subjectAngiotensin-converting enzyme-2
dc.subjectRenin-angiotensin system
dc.titleThe Contribution of the Renin-Angiotensin System to Alzheimer’s Disease
dc.typeBook Chapter

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