The Contribution of the Renin-Angiotensin System to Alzheimer’s Disease
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Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Science and Business Media Deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The renin-angiotensin system (RAS) is becoming increasingly recognised as a biochemical pathway relevant to the development and progression of Alzheimer’s disease (AD). RAS involvement in AD was initially linked to AD via numerous genetic association studies and more recent Genome-Wide Association Studies (GWAS), and in some cases in relation to classical hallmarks of AD pathology. Since these initial findings, which will be summarised here, several complementary areas of research are converging in support of what has been proposed as the Angiotensin Hypothesis for Alzheimer’s disease. This hypothesis proposes how the RAS and disease-associated changes to the normal balance between opposing regulatory pathways within RAS warrant careful consideration in the pathogenesis of AD and its pathology. We discuss some of these in relation to RAS-targeting therapeutics, originally developed for the treatment of cardiovascular conditions, and how they might be repurposed as interventions for AD. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
Açıklama
Anahtar Kelimeler
Alzheimer’s disease, Angiotensin-converting enzyme-1, Angiotensin-converting enzyme-2, Renin-angiotensin system
Kaynak
Current Topics in Behavioral Neurosciences
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
69
