Evaluation of thiol/disulfide homeostasis and ischemia modified albumin as potential markers for periodontitis

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dc.contributor.authorKarci, Bilge
dc.contributor.authorSavas, Hasan Basri
dc.date.accessioned2026-01-24T12:29:09Z
dc.date.available2026-01-24T12:29:09Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground The current study aimed to assess the impact of periodontitis on oxidative stress parameters by examining serum total antioxidant capacity (TAS), total oxidant status (TOS), oxidative stress index (OSI), thiol/ disulfide homeostasis and ischemia modified albumin (IMA). Methods The study had 90 participants, categorized into 3 groups: Group 1: Periodontally healthy; Group 2: Stage II Grade B periodontitis; Group 3: Stage III and IV Grade B periodontitis. Demographic and periodontal variables were assessed. The levels of serum TAS, TOS, OSI, IMA, and thiol/disulfide were assessed. Results No significant differences in sex and age were detected among the groups (p > 0.05). When compared to Group 1, all clinical measurements were statistically significantly greater in Group 3 (p < 0.05). Statistical analysis revealed no significant differences in serum TAS, TOS, and OSI levels among the groups (p > 0.05). The highest serum IMA value was observed in Group 3 (p = 0.037), whereas native thiol (p = 0.00), total thiol (p = 0.00) and disulfide values (p = 0.023) were highest in Group 1. Conclusions These findings indicate that thiol/disulfide homeostasis and IMA could hold promise as a potential biomarker of inflammation in periodontitis.
dc.description.sponsorshipALKU BAP
dc.description.sponsorshipNot applicable.
dc.identifier.doi10.1186/s12903-025-05875-w
dc.identifier.issn1472-6831
dc.identifier.issue1
dc.identifier.pmid40211225
dc.identifier.scopus2-s2.0-105002748371
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12903-025-05875-w
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5161
dc.identifier.volume25
dc.identifier.wosWOS:001465425400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectPeriodontitis
dc.subjectOxidative stress
dc.subjectThiol/ disulfide
dc.subjectIschemia modified albumin
dc.titleEvaluation of thiol/disulfide homeostasis and ischemia modified albumin as potential markers for periodontitis
dc.typeArticle

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