Preventive effects of systemic Pistacia eurycarpa Yalt. administration on alveolar bone loss and oxidative stress in rats with experimental periodontitis

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dc.authorid0000-0002-1411-7184
dc.authorid0000-0002-3958-4352
dc.authorid0000-0002-9042-9657
dc.authorid0000-0001-5401-0720
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorUslu, Mustafa Ozay
dc.contributor.authorIcen, Mehmet Sina
dc.contributor.authorUremis, Nuray
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2026-01-24T12:29:17Z
dc.date.available2026-01-24T12:29:17Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: This study aimed to investigate the effects of systemic administration of P. eurycarpa Yalt. plant extract on alveolar bone loss and oxidative stress biomarkers in gingival tissue in a rat model of experimental periodontitis. Methodology: 32 male Wistar albino rats, weighing 200-250 g, were divided into four groups (n=8): Healthy control (HC), Experimental periodontitis control (EPC), Experimental periodontitis 400 mg/kg (EP400), Experimental periodontitis 800 mg/kg (EP800). Experimental periodontitis was induced using the ligating method. Distilled water was administered to the HC and EPC groups and the plant extract was administered to the EP400 and EP800 groups by oral gavage at doses of 400 mg/kg and 800 mg/kg, respectively. The rats were sacrificed on the 15th day. The values of glutathione peroxidase GSH-Px, malondialdehyde (MDA), superoxide dismustase (SOD), interleukin-113 (IL-113), interleukin-10 (IL-10), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in the gingival tissues were analyzed by ELISA tests. Alveolar bone loss was assessed using micro-CT images of the maxilla. Results: Although the IL-113, TOS, OSI results of the healthy control group were lower than those of the other groups, the TAS values were higher (p<0.05). No significant difference was found in the biochemical parameters among the EPC, EP400, and EP800 groups (p>0.05). Alveolar bone loss was significantly reduced in the extract groups compared to the EPC group (p<0.001). Conclusion: Within the limitations of this study, it was observed that the systemic P. eurycarpa extract application reduced alveolar bone loss in a rat model of experimental periodontitis. Further studies are needed to elucidate the beneficial effects
dc.description.sponsorshipScientific Research Projects Coordination Unit of Inonu University [TDH-2021-2330]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Inonu University, under project number: TDH-2021-2330.
dc.identifier.doi10.1590/1678-7757-2023-0344
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid38359268
dc.identifier.scopus2-s2.0-85185232379
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2023-0344
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5235
dc.identifier.volume32
dc.identifier.wosWOS:001177281200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Sao Paulo Fac Odontologia Bauru
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAlveolar bone loss
dc.subjectPeriodontitis
dc.subjectPlant extracts
dc.subjectOxidative stress
dc.titlePreventive effects of systemic Pistacia eurycarpa Yalt. administration on alveolar bone loss and oxidative stress in rats with experimental periodontitis
dc.typeArticle

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