Investigation of the Neuroprotective Effect of Riluzole on Matrix Metalloproteinases in an Experimental Model of Glaucoma

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dc.authorid0000-0001-5562-5938
dc.contributor.authorYildiz, Fatma
dc.contributor.authorSahinoglu-Keskek, Nedime
dc.contributor.authorYilmaz, Isil Tan
dc.contributor.authorCandan, Ibrahim Aydin
dc.contributor.authorKorkmaz, Orhan Tansel
dc.date.accessioned2026-01-24T12:26:39Z
dc.date.available2026-01-24T12:26:39Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPurpose: To investigate the neuroprotective effect of riluzole through matrix metalloproteinase-2 (MMP-2) and MMP-9 in rats, in an experimental glaucoma model. Methods: A total of 28 Wistar albino rats, 3-4 months old, weighing 250-300 g, were divided into four groups; Group I (control), Group II (glaucoma), Group III (glaucoma + corn oil + dimethyl sulfoxide (DMSO), and Group IV (glaucoma + corn oil + DMSO + riluzole). A glaucoma model was created by episcleral vein cauterization in the left eyes of Group II, III, and IV subjects. After the formation of the model, daily intraperitoneal riluzole (5 mg/kg) administration was started. At the end of 7 weeks, retinal tissues were taken and some parts of them were stained with hematoxylin and eosin for histopathological examinations. In the other part, MMP-2 and MMP-9 expressions were determined using real-time quantitative PCR and immunohistochemical techniques. Results: As a result, a statistically significant increase in intraocular pressures (IOP) was found in Groups II, III, and IV when compared with the control eyes after 7 weeks (P < 0.001). There was a decrease in IOP in the riluzole group compared to the glaucoma group. Expression levels in both genes decreased slightly with riluzole administration. In the histopathological evaluation of the groups, it was observed that there were no significant differences between the findings of degeneration in ganglion cells, hemorrhage, and differentiation in layers. Conclusions: MMP-2 and MMP-9 exhibited decreased expression levels in both Group III (glaucoma + corn oil + DMSO) and Group IV (glaucoma + corn oil + DMSO + 5 mg/kg riluzole) compared to the glaucoma groups in Group II. Given that both Group III and Group IV received injections of corn oil + DMSO, this conclusion was drawn.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects (BAP) [2022-04-03-MAP04]
dc.description.sponsorshipThis study was supported by Alanya Alaaddin Keykubat University Scientific Research Projects (BAP) [project grants 2022-04-03-MAP04].
dc.identifier.doi10.4103/joco.joco_290_23
dc.identifier.endpage144
dc.identifier.issn2452-2325
dc.identifier.issue2
dc.identifier.pmid40012807
dc.identifier.scopus2-s2.0-85217046092
dc.identifier.scopusqualityQ3
dc.identifier.startpage136
dc.identifier.urihttps://doi.org/10.4103/joco.joco_290_23
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4837
dc.identifier.volume36
dc.identifier.wosWOS:001446775500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Current Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectGlaucoma
dc.subjectIntraocular pressure
dc.subjectMatrix metalloproteinase-2
dc.subjectMatrix metalloproteinase-9
dc.subjectNeuroprotection
dc.subjectRiluzole
dc.titleInvestigation of the Neuroprotective Effect of Riluzole on Matrix Metalloproteinases in an Experimental Model of Glaucoma
dc.typeArticle

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