A Silver Compound with Potential Applications as an Anticancer, Antibacterial, Antifungal, and Anti-Alzheimer's Agent

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dc.authorid0000-0002-3052-4556
dc.authorid0000-0002-7896-1042
dc.authorid0000-0002-7681-2385
dc.authorid0000-0002-6306-4760
dc.contributor.authorKorkmaz, Nesrin
dc.contributor.authorKisa, Dursun
dc.contributor.authorKaplan, Ozlem
dc.contributor.authorTosun, Nazan Goksen
dc.contributor.authorOzgur, Aykut
dc.contributor.authorImamoglu, Rizvan
dc.contributor.authorKaradag, Ahmet
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThis study investigated the biological activity of the silver coordination compound K-22. The IC50 values of K-22 on cancer cell lines range from 0.797 mu g/mL to 3.426 mu g/mL, indicating that K-22 might preferably inhibit A549, Saos-2, MCF-7, and HT-29 cell proliferation and thus have better therapeutic activity. Furthermore, K-22 stimulated apoptosis via up-regulation of the mRNA and protein expression level of Bax/Bcl-2 ratio in A549, Saos-2, MCF-7, and HT-29. K-22 exhibited antimicrobial activity against S. aureus, E. faecalis, K. pneumonia, P. aeruginosa, C. utilis, and C. albicans. Experimental results show that the compound has inhibitory potential with an IC50 value of 178.10 mu M for the BChE (butyrylcholinesterase) enzyme, which has a vital role in the progression of Alzheimer's disease. As a result, compound K-22 exhibits a strong potential for medical use due to its anticancer, antibacterial, antifungal, and anti-Alzheimer properties.
dc.identifier.doi10.1002/cbdv.202300038
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue6
dc.identifier.pmid37116090
dc.identifier.scopus2-s2.0-85159646120
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/cbdv.202300038
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5447
dc.identifier.volume20
dc.identifier.wosWOS:000991464700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectcoordination compound
dc.subjectantimicrobial agents
dc.subjectanticancer activity
dc.subjectanti-Alzheimer's compound
dc.titleA Silver Compound with Potential Applications as an Anticancer, Antibacterial, Antifungal, and Anti-Alzheimer's Agent
dc.typeArticle

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