Effect of Different Administered Doses of Capsaicin and Titanium Implant Osseointegration

Basit Öğe Kaydı
dc.authorid0000-0003-3815-8543
dc.authorid0000-0002-2925-6304
dc.authorid0000-0002-6581-2363
dc.contributor.authorBingul, Muhammet Bahattin
dc.contributor.authorGul, Mehmet
dc.contributor.authorDundar, Serkan
dc.contributor.authorSokmen, Kevser
dc.contributor.authorArtas, Goekhan
dc.contributor.authorPolat, Mehmet Emrah
dc.contributor.authorTanrisever, Murat
dc.date.accessioned2026-01-24T12:26:35Z
dc.date.available2026-01-24T12:26:35Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground and Objectives: This study aimed to evaluate the histological and biochemical effects of capsaicin on implant osseointegration and oxidative stress. Materials and Methods: Male Wistar albino rats weighing between 250 and 300 g were used in this study. Twenty-four rats were randomly divided into three equal groups: implant + control (n = 8), implant + capsaicin-1 (n = 8), and implant + capsaicin-2 (n = 8). Additionally, 2.5 mm diameter and 4 mm length titanium implants were surgically integrated into the corticocancellous bone parts of the femurs. In the treatment groups, rats were injected intraperitoneally with 25 mg/kg (implant + capsaicin-1) and 50 mg/kg (implant + capsaicin-2) of capsaicin. No additional applications were made in the control group. Three rats in total died during and after the experiment as a result of the analyses performed on 21 animals. Results: The highest total antioxidant status value was found in capsaicin dose 2, according to the analysis. The control group had the highest total oxidant status and oxidative stress index values, while group 2 of capsaicin had the lowest. After analysis, we found that there was no observed positive effect on osteointegration in this study (p > 0.05), although the bone implant connection was higher in the groups treated with capsaicin. Conclusions: A positive effect on osteointegration was not observed in this study. This may be due to osteoclast activation. However, it was found that it has a positive effect on oxidative stress. Osteoclast activation may be the cause of this phenomenon. Capsaicin was found to have a positive effect on oxidative stress (p < 0.05). It was also observed to have a positive effect on oxidative stress.
dc.description.sponsorshipThe authors wish to thank Implance Dental Implant System, AGS Medical Corporation, Istanbul, Turkey, for providing the titanium implants. This study was presented at the 14th International Online Congress of ACBD.
dc.identifier.doi10.3390/medicina60071094
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue7
dc.identifier.pmid39064523
dc.identifier.scopus2-s2.0-85199868429
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina60071094
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4775
dc.identifier.volume60
dc.identifier.wosWOS:001278688100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectcapsaicin
dc.subjectoxidative stress
dc.subjectosseointegration
dc.subjectbone implant connection
dc.titleEffect of Different Administered Doses of Capsaicin and Titanium Implant Osseointegration
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu