Detection of High-Risk Human Papillomavirus (HPV), p16 and EGFR in Lung Cancer: Insights from the Mediterranean Region of Turkey

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dc.contributor.authorAlikanoglu, Arsenal Sezgin
dc.contributor.authorKaracay, Irem Atalay
dc.date.accessioned2026-01-24T12:26:36Z
dc.date.available2026-01-24T12:26:36Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractHuman papillomavirus (HPV) is an oncogenic DNA virus that plays a role in different cancer types. The aim of this study was to detect the prevalence and types of HPV and its relation with p16, EGFR and clinical findings in lung cancer. HPV and EGFR detection and genotyping of HPV were performed by polymerase chain reaction (PCR) and p16 by immunohistochemistry. Fifty lung cancer patients and seven patients with non-neoplastic lung disease were enrolled in this study. HPV was positive in 78% (39/50) of lung cancer cases. HPV 51 was the most frequent type, followed by HPV 16. Moreover, p16 was positive in 24% (12/50) of the cancer patients, and all of these patients were HPV-positive, while 27 HPV-positive patients showed no p16 expression. There was no relationship between HPV infection and p16 (p = 0.05), gender (p = 0.42), age (p = 0.38), or smoking history (p = 0.68). Although not statistically significant, the HPV prevalence was found to be higher in cancer patients compared to non-neoplastic patients. The prevalence of HPV in lung cancer varies across different studies, which may be due to differences in the detection methods, number of patients, geographic regions, and vaccination status. Further studies are necessary to understand the role of HPV in lung cancer pathogenesis.
dc.identifier.doi10.3390/v16081201
dc.identifier.issn1999-4915
dc.identifier.issue8
dc.identifier.pmid39205175
dc.identifier.scopus2-s2.0-85202464254
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/v16081201
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4798
dc.identifier.volume16
dc.identifier.wosWOS:001307439400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofViruses-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectlung cancer
dc.subjecthuman papillomavirus (HPV)
dc.subjectpolymerase chain reaction (PCR)
dc.subjectviral oncology
dc.subjectp16 protein
dc.titleDetection of High-Risk Human Papillomavirus (HPV), p16 and EGFR in Lung Cancer: Insights from the Mediterranean Region of Turkey
dc.typeArticle

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